Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials
Perindopril/indapamide combination has been shown to reduce cardiovascular risk in different groups of patients. A total of 18,529 patients (9,272 receiving perindopril/indapamide and 9,257 receiving placebo) were included in this meta-analysis involving three large randomized clinical trials-ADVANC...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2011-07-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/7920 |
| _version_ | 1828758348118360064 |
|---|---|
| author | Sougat Sourendra Sarkar |
| author_facet | Sougat Sourendra Sarkar |
| author_sort | Sougat Sourendra Sarkar |
| collection | DOAJ |
| description | Perindopril/indapamide combination has been shown to reduce cardiovascular risk in different groups of patients. A total of 18,529 patients (9,272 receiving perindopril/indapamide and 9,257 receiving placebo) were included in this meta-analysis involving three large randomized clinical trials-ADVANCE, PROGRESS and HYVET. A non-significant reduction in fatal and non-fatal stroke was seen (Odds ratio 0.73; 95% Confidence Interval 0.49 to 1.09; z=1.52 and p= 0.13). The combination was associated with a significantly reduction of vascular death (Odds ratio 0.79; 95% Confidence Interval 0.69 to 0.90; z=3.48 and p=0.0005) and major cardio-vascular events (Odds ratio 0.72; 95% Confidence Interval 0.53 to 0.97; z=2.15 and p= 0.03). Fixed-combination of Perindopril and indapamide substantially reduced major cardiovascular event and vascular death. However, effect on stroke needs further evaluation. |
| first_indexed | 2024-12-11T00:40:26Z |
| format | Article |
| id | doaj.art-7969773877424687a29fcbbb9ebb945d |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-11T00:40:26Z |
| publishDate | 2011-07-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-7969773877424687a29fcbbb9ebb945d2022-12-22T01:26:57ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882011-07-016110.3329/bjp.v6i1.7920Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trialsSougat Sourendra Sarkar0Glenmark Pharmaceuticals Ltd, Glenmark House, Mumbai,Perindopril/indapamide combination has been shown to reduce cardiovascular risk in different groups of patients. A total of 18,529 patients (9,272 receiving perindopril/indapamide and 9,257 receiving placebo) were included in this meta-analysis involving three large randomized clinical trials-ADVANCE, PROGRESS and HYVET. A non-significant reduction in fatal and non-fatal stroke was seen (Odds ratio 0.73; 95% Confidence Interval 0.49 to 1.09; z=1.52 and p= 0.13). The combination was associated with a significantly reduction of vascular death (Odds ratio 0.79; 95% Confidence Interval 0.69 to 0.90; z=3.48 and p=0.0005) and major cardio-vascular events (Odds ratio 0.72; 95% Confidence Interval 0.53 to 0.97; z=2.15 and p= 0.03). Fixed-combination of Perindopril and indapamide substantially reduced major cardiovascular event and vascular death. However, effect on stroke needs further evaluation.https://www.banglajol.info/index.php/BJP/article/view/7920IndapamideMeta-analysisPerindoprilPreventionStrokeVascular disease |
| spellingShingle | Sougat Sourendra Sarkar Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials Bangladesh Journal of Pharmacology Indapamide Meta-analysis Perindopril Prevention Stroke Vascular disease |
| title | Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials |
| title_full | Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials |
| title_fullStr | Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials |
| title_full_unstemmed | Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials |
| title_short | Combination of perindopril/indapamide in secondary prevention of stroke and other vascular events: A combined analysis of ADVANCE, PROGRESS and HYVET trials |
| title_sort | combination of perindopril indapamide in secondary prevention of stroke and other vascular events a combined analysis of advance progress and hyvet trials |
| topic | Indapamide Meta-analysis Perindopril Prevention Stroke Vascular disease |
| url | https://www.banglajol.info/index.php/BJP/article/view/7920 |
| work_keys_str_mv | AT sougatsourendrasarkar combinationofperindoprilindapamideinsecondarypreventionofstrokeandothervasculareventsacombinedanalysisofadvanceprogressandhyvettrials |