Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms
Nowadays, sustainable materials are receiving significant attention due to the fact that they will be crucial for the development of the next generation of products and devices. In the present work, hydrogels have been successfully synthesized using lignin which is non-valorized biopolymer from the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/6/1593 |
| _version_ | 1797541471921897472 |
|---|---|
| author | Mario Culebras Mahboubeh Pishnamazi Gavin M. Walker Maurice N. Collins |
| author_facet | Mario Culebras Mahboubeh Pishnamazi Gavin M. Walker Maurice N. Collins |
| author_sort | Mario Culebras |
| collection | DOAJ |
| description | Nowadays, sustainable materials are receiving significant attention due to the fact that they will be crucial for the development of the next generation of products and devices. In the present work, hydrogels have been successfully synthesized using lignin which is non-valorized biopolymer from the paper industry. Hydrogels were prepared via crosslinking with Poly(ethylene) glycol diglycidyl ether (PEGDGE). Different crosslinker ratios were used to determine their influence on the structural and chemical properties of the resulting hydrogels. It has been found that pore size was reduced by increasing crosslinker amount. The greater crosslinking density increased the swelling capacity of the hydrogels due to the presence of more hydrophilic groups in the hydrogel network. Paracetamol release test showed higher drug diffusion for hydrogels produced with a ratio lignin:PEGDGE 1:1. The obtained results demonstrate that the proposed approach is a promising route to utilize lignocellulose waste for producing porous materials for advanced biomedical applications in the pharmacy industry. |
| first_indexed | 2024-03-10T13:16:30Z |
| format | Article |
| id | doaj.art-7969e32641eb49ff8cfc639abf37d418 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:16:30Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7969e32641eb49ff8cfc639abf37d4182023-11-21T10:22:25ZengMDPI AGMolecules1420-30492021-03-01266159310.3390/molecules26061593Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived PlatformsMario Culebras0Mahboubeh Pishnamazi1Gavin M. Walker2Maurice N. Collins3Stokes Laboratories, School of Engineering, Bernal Institute and AMBER, University of Limerick, V94 T9PX Limerick, IrelandPharmaceutical Centre (SSPC), University of Limerick, V94 T9PX Limerick, IrelandPharmaceutical Centre (SSPC), University of Limerick, V94 T9PX Limerick, IrelandStokes Laboratories, School of Engineering, Bernal Institute and AMBER, University of Limerick, V94 T9PX Limerick, IrelandNowadays, sustainable materials are receiving significant attention due to the fact that they will be crucial for the development of the next generation of products and devices. In the present work, hydrogels have been successfully synthesized using lignin which is non-valorized biopolymer from the paper industry. Hydrogels were prepared via crosslinking with Poly(ethylene) glycol diglycidyl ether (PEGDGE). Different crosslinker ratios were used to determine their influence on the structural and chemical properties of the resulting hydrogels. It has been found that pore size was reduced by increasing crosslinker amount. The greater crosslinking density increased the swelling capacity of the hydrogels due to the presence of more hydrophilic groups in the hydrogel network. Paracetamol release test showed higher drug diffusion for hydrogels produced with a ratio lignin:PEGDGE 1:1. The obtained results demonstrate that the proposed approach is a promising route to utilize lignocellulose waste for producing porous materials for advanced biomedical applications in the pharmacy industry.https://www.mdpi.com/1420-3049/26/6/1593ligninhydrogelscrosslinkingdrug release |
| spellingShingle | Mario Culebras Mahboubeh Pishnamazi Gavin M. Walker Maurice N. Collins Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms Molecules lignin hydrogels crosslinking drug release |
| title | Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms |
| title_full | Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms |
| title_fullStr | Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms |
| title_full_unstemmed | Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms |
| title_short | Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms |
| title_sort | facile tailoring of structures for controlled release of paracetamol from sustainable lignin derived platforms |
| topic | lignin hydrogels crosslinking drug release |
| url | https://www.mdpi.com/1420-3049/26/6/1593 |
| work_keys_str_mv | AT marioculebras faciletailoringofstructuresforcontrolledreleaseofparacetamolfromsustainableligninderivedplatforms AT mahboubehpishnamazi faciletailoringofstructuresforcontrolledreleaseofparacetamolfromsustainableligninderivedplatforms AT gavinmwalker faciletailoringofstructuresforcontrolledreleaseofparacetamolfromsustainableligninderivedplatforms AT mauricencollins faciletailoringofstructuresforcontrolledreleaseofparacetamolfromsustainableligninderivedplatforms |