Researches on cognitive sequelae of burn injury: Current status and advances
Burn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary periphera...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1026152/full |
| _version_ | 1811244215237083136 |
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| author | Chenchen Xie Chenchen Xie Jun Hu Yong Cheng Zhongxiang Yao |
| author_facet | Chenchen Xie Chenchen Xie Jun Hu Yong Cheng Zhongxiang Yao |
| author_sort | Chenchen Xie |
| collection | DOAJ |
| description | Burn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary peripheral factors and the secondary cerebral inflammation, resulting in the destruction of blood-brain barrier (BBB), as is shown on Computed Tomography (CT) and magnetic resonance imaging examinations. As part of the neurovascular unit, BBB is vital to the nutrition and homeostasis of the central nervous system (CNS) and undergoes myriad alterations after burn injury, causing post-burn cognitive defects. The diagnosis and treatment of cognitive dysfunctions as burn injury sequelae are of great importance. In this review, we address the major manifestations and interventions of post-burn cognitive defects, as well as the mechanisms involved in memory defect, including neuroinflammation, destruction of BBB, and hormone imbalance. |
| first_indexed | 2024-04-12T14:20:53Z |
| format | Article |
| id | doaj.art-796a217bfe5b4cf386cac1657672b4c0 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T14:20:53Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-796a217bfe5b4cf386cac1657672b4c02022-12-22T03:29:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.10261521026152Researches on cognitive sequelae of burn injury: Current status and advancesChenchen Xie0Chenchen Xie1Jun Hu2Yong Cheng3Zhongxiang Yao4Department of Neurology, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, First Affiliated Hospital of Army Medical University, Chongqing, ChinaDepartment of Neurology, General Hospital of Central Theater Command of PLA, Wuhan, ChinaDepartment of Physiology, Army Medical University, Chongqing, ChinaBurn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary peripheral factors and the secondary cerebral inflammation, resulting in the destruction of blood-brain barrier (BBB), as is shown on Computed Tomography (CT) and magnetic resonance imaging examinations. As part of the neurovascular unit, BBB is vital to the nutrition and homeostasis of the central nervous system (CNS) and undergoes myriad alterations after burn injury, causing post-burn cognitive defects. The diagnosis and treatment of cognitive dysfunctions as burn injury sequelae are of great importance. In this review, we address the major manifestations and interventions of post-burn cognitive defects, as well as the mechanisms involved in memory defect, including neuroinflammation, destruction of BBB, and hormone imbalance.https://www.frontiersin.org/articles/10.3389/fnins.2022.1026152/fullburn injurycognitive dysfunctionneuroinflammationblood-brain barrier (BBB)hormone imbalancememory defect |
| spellingShingle | Chenchen Xie Chenchen Xie Jun Hu Yong Cheng Zhongxiang Yao Researches on cognitive sequelae of burn injury: Current status and advances Frontiers in Neuroscience burn injury cognitive dysfunction neuroinflammation blood-brain barrier (BBB) hormone imbalance memory defect |
| title | Researches on cognitive sequelae of burn injury: Current status and advances |
| title_full | Researches on cognitive sequelae of burn injury: Current status and advances |
| title_fullStr | Researches on cognitive sequelae of burn injury: Current status and advances |
| title_full_unstemmed | Researches on cognitive sequelae of burn injury: Current status and advances |
| title_short | Researches on cognitive sequelae of burn injury: Current status and advances |
| title_sort | researches on cognitive sequelae of burn injury current status and advances |
| topic | burn injury cognitive dysfunction neuroinflammation blood-brain barrier (BBB) hormone imbalance memory defect |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1026152/full |
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