The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD
<p>Abstract</p> <p>Background</p> <p>This study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD.</p> <p>Methods</p> <p>One hundred...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/8/1/25 |
| _version_ | 1818752217903005696 |
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| author | Matthews Natasha Vance Alasdair Cummins Tarrant D R Wagner Joseph Connolly Amanda Yamada Jacqueline Lockhart Paul J Panwar Ajay Wallace Robyn H Bellgrove Mark A |
| author_facet | Matthews Natasha Vance Alasdair Cummins Tarrant D R Wagner Joseph Connolly Amanda Yamada Jacqueline Lockhart Paul J Panwar Ajay Wallace Robyn H Bellgrove Mark A |
| author_sort | Matthews Natasha |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD.</p> <p>Methods</p> <p>One hundred and eighteen children with ADHD performed three working memory measures taken from the CANTAB battery (Spatial Span, Delayed-match-to-sample, and Spatial Working Memory). Associations between performance on working memory measures and allelic variation in catecholamine genes (including those for the noradrenaline transporter [NET1], the dopamine D4 and D2 receptor genes [DRD4; DRD2], the gene encoding dopamine beta hydroxylase [DBH] and catechol-O-methyl transferase [COMT]) were investigated using regression models that controlled for age, IQ, gender and medication status on the day of test.</p> <p>Results</p> <p>Significant associations were found between performance on the delayed-match-to-sample task and COMT genotype. More specifically, <it>val/val</it> homozygotes produced significantly more errors than did children who carried a least one <it>met</it> allele. There were no further associations between allelic variants and performance across the other working memory tasks.</p> <p>Conclusions</p> <p>The working memory measures employed in the present study differed in the degree to which accurate task performance depended upon either the dynamic updating and/or manipulation of items in working memory, as in the spatial span and spatial working memory tasks, or upon the stable maintenance of representations, as in the delay-match–to-sample task. The results are interpreted as evidence of a relationship between tonic dopamine levels associated with the <it>met</it> COMT allele and the maintenance of stable working memory representations required to perform the delayed-match-to-sample-task.</p> |
| first_indexed | 2024-12-18T04:47:58Z |
| format | Article |
| id | doaj.art-796aba9bb67b41f0abf24752c213d5c1 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-18T04:47:58Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-796aba9bb67b41f0abf24752c213d5c12022-12-21T21:20:31ZengBMCBehavioral and Brain Functions1744-90812012-05-01812510.1186/1744-9081-8-25The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHDMatthews NatashaVance AlasdairCummins Tarrant D RWagner JosephConnolly AmandaYamada JacquelineLockhart Paul JPanwar AjayWallace Robyn HBellgrove Mark A<p>Abstract</p> <p>Background</p> <p>This study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD.</p> <p>Methods</p> <p>One hundred and eighteen children with ADHD performed three working memory measures taken from the CANTAB battery (Spatial Span, Delayed-match-to-sample, and Spatial Working Memory). Associations between performance on working memory measures and allelic variation in catecholamine genes (including those for the noradrenaline transporter [NET1], the dopamine D4 and D2 receptor genes [DRD4; DRD2], the gene encoding dopamine beta hydroxylase [DBH] and catechol-O-methyl transferase [COMT]) were investigated using regression models that controlled for age, IQ, gender and medication status on the day of test.</p> <p>Results</p> <p>Significant associations were found between performance on the delayed-match-to-sample task and COMT genotype. More specifically, <it>val/val</it> homozygotes produced significantly more errors than did children who carried a least one <it>met</it> allele. There were no further associations between allelic variants and performance across the other working memory tasks.</p> <p>Conclusions</p> <p>The working memory measures employed in the present study differed in the degree to which accurate task performance depended upon either the dynamic updating and/or manipulation of items in working memory, as in the spatial span and spatial working memory tasks, or upon the stable maintenance of representations, as in the delay-match–to-sample task. The results are interpreted as evidence of a relationship between tonic dopamine levels associated with the <it>met</it> COMT allele and the maintenance of stable working memory representations required to perform the delayed-match-to-sample-task.</p>http://www.behavioralandbrainfunctions.com/content/8/1/25Attention-deficit-hyperactivity-disorderWorking memoryCOMT |
| spellingShingle | Matthews Natasha Vance Alasdair Cummins Tarrant D R Wagner Joseph Connolly Amanda Yamada Jacqueline Lockhart Paul J Panwar Ajay Wallace Robyn H Bellgrove Mark A The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD Behavioral and Brain Functions Attention-deficit-hyperactivity-disorder Working memory COMT |
| title | The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD |
| title_full | The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD |
| title_fullStr | The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD |
| title_full_unstemmed | The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD |
| title_short | The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD |
| title_sort | comt val158 allele is associated with impaired delayed match to sample performance in adhd |
| topic | Attention-deficit-hyperactivity-disorder Working memory COMT |
| url | http://www.behavioralandbrainfunctions.com/content/8/1/25 |
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