A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge <i>Stylissa massa</i>

A Series of New Pyrrole Alkaloids with ALR2 Inhibitory Activities from the Sponge <i>Stylissa massa</i>

Twelve new and four known alkaloids including five different structural scaffolds were isolated from the sponge <i>Stylissa massa</i> collected in the South China Sea. Compound <b>1</b> is the first identified precursor metabolite of the classic 5/7/5 tricyclic skeleton with...

Full description

Bibliographic Details
Main Authors:	Qi Wang, Chunhua Gao, Zhun Wei, Xiaowen Tang, Lixia Ji, Xiangchao Luo, Xiaoping Peng, Gang Li, Hongxiang Lou
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Series:	Marine Drugs
Subjects:	pyrrole-imidazole alkaloids ALR2 inhibitory activities sponge <i>Stylissa massa</i> spongiacidin
Online Access:	https://www.mdpi.com/1660-3397/20/7/454

Similar Items

Antimalarial Activity of Sea Sponge Extract of Stylissa massa originating from waters of Rote Island
by: Jefry Presson, et al.
Published: (2021-04-01)

A Submarine Journey: The Pyrrole-Imidazole Alkaloids
by: Alessandra Scolaro, et al.
Published: (2009-11-01)

New Cytotoxic Natural Products from the Red Sea Sponge <i>Stylissa carteri</i>
by: Reda F. A. Abdelhameed, et al.
Published: (2020-05-01)

The marine sponge Agelas citrina as a source of the new pyrrole–imidazole alkaloids citrinamines A–D and N-methylagelongine
by: Christine Cychon, et al.
Published: (2015-10-01)

Marine Pyrrole Alkaloids
by: Kevin Seipp, et al.
Published: (2021-09-01)

Substituent-Controllable Cascade Regioselective Annulation of <i>β</i>-Enaminones with <i>N</i>-Sulfonyl Triazoles for Modular Access to Imidazoles and Pyrroles
by: Hua Wang, et al.
Published: (2023-05-01)

Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1)
by: Aubrie O’Rourke, et al.
Published: (2016-02-01)

<i>Alr</i> Gene in <i>Brucella suis</i> S2: Its Role in Lipopolysaccharide Biosynthesis and Bacterial Virulence in RAW264.7
by: Mingyue Hao, et al.
Published: (2023-06-01)

(10<i>Z</i>)-Debromohymenialdisine from Marine Sponge <i>Stylissa</i> sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells
by: Seon Min Lee, et al.
Published: (2019-09-01)

The ethyl acetate fraction of sponge Stylissa carteri decreases viability in HER2+ trastuzumab-resistant breast cancer cells
by: Julia Nur Jannah, et al.
Published: (2019-12-01)

The Road Not Taken with Pyrrole-Imidazole Polyamides: Off-Target Effects and Genomic Binding
by: Jason Lin, et al.
Published: (2020-04-01)

Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
by: Rocco Vitalone, et al.
Published: (2012-11-01)

1-Phenyl-3-tosyl-1<i>H</i>-pyrrole
by: Zoumpoulia Kechagioglou, et al.
Published: (2022-10-01)

In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge <i>Agelas dilatata</i>, against <i>Pseudomonas aeruginosa</i>
by: Dawrin Pech-Puch, et al.
Published: (2020-06-01)

Preliminary development plan of the ALR, the laser rangefinder for the ASTER deep space mission to the 2001 SN263 asteroid
by: Antonio Gil Vicente de Brum, et al.
Published: (2011-09-01)

Bromopyrrole Alkaloids from the Sponge <em>Agelas kosrae</em>
by: Oh-Seok Kwon, et al.
Published: (2018-12-01)

The chemistry of pyrroles/
by: 319790 Jones, R. Alan, et al.
Published: (1977)

1-Methylimidazole as an Organic Catalyst for [3+3]-Cyclodimerization of Acylethynylpyrroles to Bis(acylmethylidene)dipyrrolo[1,2-<i>a</i>:1′,2′-<i>d</i>]pyrazines
by: Kseniya V. Belyaeva, et al.
Published: (2022-12-01)

Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge <i>Scalarispongia</i> sp.
by: Yeon-Ju Lee, et al.
Published: (2019-02-01)

First Total Synthesis and Biological Screening of a Proline-Rich Cyclopeptide from a Caribbean Marine Sponge
by: Rajiv Dahiya, et al.
Published: (2016-12-01)

PRELIMINARY DEVELOPMENT PLAN OF THE ALR, THE LASER RANGEFINDER FOR THE ASTER DEEP SPACE MISSION TO THE 2001 SN263 ASTEROID. DOI: 10.5028/jatm.2011.03033611
by: Antonio Gil Vicente de Brum, et al.
Published: (2012-01-01)

Contribution of TGF-β1 and Effects of Gene Silencer Pyrrole-Imidazole Polyamides Targeting TGF-β1 in Diabetic Nephropathy
by: Shu Horikoshi, et al.
Published: (2020-02-01)

The <i>N</i>-Alkylation of Agelastatin A Modulates Its Chemical Reactivity
by: Michele D’Ambrosio
Published: (2023-09-01)

4′-(<i>N</i>-(Propargyl)pyrrol-2-yl)-2,2′:6′,2′′-terpyridine
by: Jérôme Husson, et al.
Published: (2022-03-01)

Synthesis of novel pyrroles and fused pyrroles as antifungal and antibacterial agents
by: Rania Helmy Abd El-Hameed, et al.
Published: (2021-01-01)

Synthesis and rearrangement of 2-(arylsulfinyl)- and 2-(alkylsulfinyl) pyrroles /
by: Carmona, Olga

Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset
by: Masari Otsuki, et al.
Published: (2019-09-01)

Synthesis and Anti-Tuberculosis Activity of Substituted 3,4-(dicoumarin-3-yl)-2,5-diphenyl Furans and Pyrroles
by: Bhagwat Jadhav, et al.
Published: (2022-12-01)

Substituted Pyrroles
by: O. A. Golubchicov, et al.
Published: (2000-01-01)

Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid
by: Lin Zhu, et al.
Published: (2022-05-01)

Synthesis of Pyridoxine-Derived Dimethylpyridinols Fused with Aminooxazole, Aminoimidazole, and Aminopyrrole
by: Bhuwan Prasad Awasthi, et al.
Published: (2022-03-01)

Identification of a Novel Pyrrole Alkaloid from the Edible Mushroom <i>Basidiomycetes-X</i> (Echigoshirayukidake)
by: Toshio Sakamoto, et al.
Published: (2020-10-01)

An Efficient and Short Route for the Synthesis of Reverse Pyrrole Ribonucleosides
by: Pereira Letícia O. R., et al.
Published: (2002-01-01)

Solvent Free Three-Component Synthesis of 2,4,5-trisubstituted-1<i>H</i>-pyrrol-3-ol-type Compounds from <i>L</i>-tryptophan: DFT-B3LYP Calculations for the Reaction Mechanism and 3<i>H</i>-pyrrol-3-one↔1<i>H</i>-pyrrol-3-ol Tautomeric Equilibrium
by: Diego Quiroga, et al.
Published: (2020-09-01)

Regulation of the Gene for Alanine Racemase Modulates Amino Acid Metabolism with Consequent Alterations in Cell Wall Properties and Adhesive Capability in <i>Brucella</i> spp.
by: Mingyue Hao, et al.
Published: (2023-11-01)

Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter
by: Makiyo Okamura, et al.
Published: (2021-04-01)

Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma
by: Akiko Tsujimoto, et al.
Published: (2023-03-01)

Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-<i>b</i>]pyrrole Chelators
by: Veronika Antonyová, et al.
Published: (2022-09-01)

An Efficient Synthesis of Aryl-Substituted Pyrroles by the Suzuki–Miyaura Coupling Reaction of SEM-Protected Pyrroles
by: Keli Cui, et al.
Published: (2019-04-01)

The first direct synthesis of β-unsubstituted meso-decamethylcalix[5]pyrrole
by: Luis Chacón-García, et al.
Published: (2009-01-01)