| Summary: | <p>Abstract</p> <p>Background</p> <p>Overweight and obesity are established risk factors for insulin resistance in youth. A number of behavioral recommendations have been publicized with the goal of improving glycemic control. However, there is limited information about whether meeting these behavioral recommendations actually reduces insulin resistance.</p> <p>Findings</p> <p>92 youths 11 - 16 years with BMI ≥ 85% underwent oral glucose tolerance testing. HOMA-IR and AUC<sub>Insulin</sub>/AUC<sub>Glucose </sub>were calculated as measures of insulin resistance. Dietary and physical activity (PA) measures were performed. Assessments included whether or not participants met recommended levels of diet, PA and sedentary behaviors.</p> <p>62% youths met criteria for insulin resistance. 82% (75/92) met at least one behavioral recommendation. Participants who met ≥ 1 dietary, sedentary, or PA recommendations had significantly reduced insulin resistance as compared with youth who did not. This relationship remained significant in multivariate modeling of insulin resistance adjusting for age, sex, and BMI.</p> <p>Conclusions</p> <p>Even relatively minor behavior change may reduce insulin resistance in youth at risk for diabetes. Our findings support the relevance of current behavioral interventions for glycemic control.</p> <p>Trials Registration</p> <p>Clinical Trials <a href="http://www.clinicaltrials.gov/ct2/show/#NCT00412165">#NCT00412165</a>.</p>
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