Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1)

Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1)

Abstract Objective Peritoneal fibrosis remains a serious complication of long-term peritoneal dialysis (PD) leading to peritoneal membrane ultrafiltration failure. Epithelial–mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a key process of peritoneal fibrosis. Curcumin has bee...

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Bibliographic Details
Main Authors: Jun-Li Zhao, Mei-Zi Guo, Jun-Jun Zhu, Ting Zhang, Dan-Yan Min
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
Peritoneal fibrosis (PF)
Peritoneal dialysis
Epithelial-mesenchymal transition (EMT)
Curcumin
TGF-β-activated kinase 1 (TAK1)
Online Access:http://link.springer.com/article/10.1186/s11658-019-0157-x

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