Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells

Hsp70 Interacts with the TREM-1 Receptor Expressed on Monocytes and Thereby Stimulates Generation of Cytotoxic Lymphocytes Active against MHC-Negative Tumor Cells

The search for and analysis of new ligands for innate immunity receptors are of special significance for understanding the regulatory mechanisms of immune response. Here we show that the major heat shock protein 70 (Hsp70) can bind to and activate TREM-1, the innate immunity receptor expressed on mo...

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Bibliographic Details
Main Authors: Tatiana N. Sharapova, Elena A. Romanova, Olga K. Ivanova, Denis V. Yashin, Lidia P. Sashchenko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
monocytes
Hsp70
NK
cytotoxicity
cytokine
Online Access:https://www.mdpi.com/1422-0067/22/13/6889

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