Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease
(1) Background: Gastroesophageal reflux disease (GERD) can cause several complications as a result of the acidic pH over various cellular structures, which have been demonstrated and evaluated over time. Anemia can occur due to iron loss from erosions caused by acidic gastric content. In children, a...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/1/63 |
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| author | Vasile Valeriu Lupu Ingrith Miron Ana Maria Laura Buga Cristina Gavrilovici Elena Tarca Anca Adam Raileanu Iuliana Magdalena Starcea Andrei Tudor Cernomaz Adriana Mocanu Ancuta Lupu |
| author_facet | Vasile Valeriu Lupu Ingrith Miron Ana Maria Laura Buga Cristina Gavrilovici Elena Tarca Anca Adam Raileanu Iuliana Magdalena Starcea Andrei Tudor Cernomaz Adriana Mocanu Ancuta Lupu |
| author_sort | Vasile Valeriu Lupu |
| collection | DOAJ |
| description | (1) Background: Gastroesophageal reflux disease (GERD) can cause several complications as a result of the acidic pH over various cellular structures, which have been demonstrated and evaluated over time. Anemia can occur due to iron loss from erosions caused by acidic gastric content. In children, anemia has consequences that, in time, can affect their normal development. This study evaluates the presence of anemia as a result of pediatric gastroesophageal reflux disease. (2) Methods: 172 children were diagnosed with gastroesophageal reflux in the gastroenterology department of a regional children’s hospital in northeast Romania by esophageal pH-metry and they were evaluated for presence of anemia. (3) Results: 23 patients with GERD from the studied group also had anemia, showing a moderate correlation (r = −0.35, <i>p</i> = 0.025, 95% confidence interval) and lower levels of serum iron were found in cases with GERD, with statistical significance (F = 8.46, <i>p</i> = 0.012, 95% confidence interval). (4) Conclusions: The results of our study suggest that there is a relationship between anemia or iron deficiency and gastroesophageal reflux due to reflux esophagitis in children, which needs to be further studied in larger groups to assess the repercussions on children’s development. |
| first_indexed | 2024-03-11T10:04:59Z |
| format | Article |
| id | doaj.art-797790ae49214c45824276733335d7ab |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T10:04:59Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-797790ae49214c45824276733335d7ab2023-11-16T15:08:18ZengMDPI AGDiagnostics2075-44182022-12-011316310.3390/diagnostics13010063Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux DiseaseVasile Valeriu Lupu0Ingrith Miron1Ana Maria Laura Buga2Cristina Gavrilovici3Elena Tarca4Anca Adam Raileanu5Iuliana Magdalena Starcea6Andrei Tudor Cernomaz7Adriana Mocanu8Ancuta Lupu9Pediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Surgery II—Pediatric Surgery, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania3rd Medical Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics Department, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania(1) Background: Gastroesophageal reflux disease (GERD) can cause several complications as a result of the acidic pH over various cellular structures, which have been demonstrated and evaluated over time. Anemia can occur due to iron loss from erosions caused by acidic gastric content. In children, anemia has consequences that, in time, can affect their normal development. This study evaluates the presence of anemia as a result of pediatric gastroesophageal reflux disease. (2) Methods: 172 children were diagnosed with gastroesophageal reflux in the gastroenterology department of a regional children’s hospital in northeast Romania by esophageal pH-metry and they were evaluated for presence of anemia. (3) Results: 23 patients with GERD from the studied group also had anemia, showing a moderate correlation (r = −0.35, <i>p</i> = 0.025, 95% confidence interval) and lower levels of serum iron were found in cases with GERD, with statistical significance (F = 8.46, <i>p</i> = 0.012, 95% confidence interval). (4) Conclusions: The results of our study suggest that there is a relationship between anemia or iron deficiency and gastroesophageal reflux due to reflux esophagitis in children, which needs to be further studied in larger groups to assess the repercussions on children’s development.https://www.mdpi.com/2075-4418/13/1/63gastroesophageal refluxanemiaesophagitischildren |
| spellingShingle | Vasile Valeriu Lupu Ingrith Miron Ana Maria Laura Buga Cristina Gavrilovici Elena Tarca Anca Adam Raileanu Iuliana Magdalena Starcea Andrei Tudor Cernomaz Adriana Mocanu Ancuta Lupu Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease Diagnostics gastroesophageal reflux anemia esophagitis children |
| title | Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease |
| title_full | Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease |
| title_fullStr | Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease |
| title_full_unstemmed | Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease |
| title_short | Iron Deficiency Anemia in Pediatric Gastroesophageal Reflux Disease |
| title_sort | iron deficiency anemia in pediatric gastroesophageal reflux disease |
| topic | gastroesophageal reflux anemia esophagitis children |
| url | https://www.mdpi.com/2075-4418/13/1/63 |
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