Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages

Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages

Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer and demonstrates high resistance to radiation and chemotherapy. These tumors evade immune system detection by promoting an immunosuppressive tumor microenvironment. Genetic analysis has revealed oncogenic activation of the R...

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Bibliographic Details
Main Authors: Dörthe Masemann, Katharina Köther, Meike Kuhlencord, Georg Varga, Johannes Roth, Brian Dennis Lichty, Ulf Rüdiger Rapp, Viktor Wixler, Stephan Ludwig
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
influenza a viruses
lung cancer
oncolytic viruses
immunotherapy
virotherapy
immune cell polarization
tumor-associated macrophages
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1423171

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