Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug

Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug

Abstract Background The most common gene responsible for autosomal recessive retinitis pigmentosa (RP) is EYS. The manner of decay of genetically defective EYS gene transcripts varies depending on the type of mutation using our cellular model, which consists of induced photoreceptor-directed fibrobl...

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Bibliographic Details
Main Authors: Dilip Rai, Masaki Iwanami, Yoriko Takahashi, Yukari Komuta, Noriyuki Aoi, Akihiro Umezawa, Yuko Seko
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Stem Cell Research & Therapy
Subjects:
Redirect differentiation
Dermal fibroblast
Photoreceptor
Disease modeling
Retinitis pigmentosa
EYS
Online Access:https://doi.org/10.1186/s13287-022-02827-x

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