The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer
It is well known that long non-coding RNAs (lncRNAs) play an important role in the regulation of tumor genesis and development. They can modulate gene expression of transcriptional regulation, epigenetic regulation of chromatin modification, and post-transcriptional regulation, thus influencing the...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253122000610 |
| _version_ | 1818264925837983744 |
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| author | Junxia Liu Qinqiu Zhang Daolu Yang Fei Xie Zhaoxia Wang |
| author_facet | Junxia Liu Qinqiu Zhang Daolu Yang Fei Xie Zhaoxia Wang |
| author_sort | Junxia Liu |
| collection | DOAJ |
| description | It is well known that long non-coding RNAs (lncRNAs) play an important role in the regulation of tumor genesis and development. They can modulate gene expression of transcriptional regulation, epigenetic regulation of chromatin modification, and post-transcriptional regulation, thus influencing the biological behavior of tumors, such as cell proliferation, apoptosis, cell cycle, invasion, and migration. Tumor angiogenesis not only provides nutrients and helps excrete metabolites, but it also opens a pathway for tumor metastasis. Anti-angiogenic therapy has become one of the effective treatment methods for tumor. But its drug resistance leads to the limitation of clinical application. Recent studies have shown that lncRNAs are closely related to tumor angiogenesis and anti-angiogenic therapy resistance, which provides a new direction for tumor research. lncRNAs are expected to be new targets for tumor therapy. For the first time to our knowledge, this paper reviews advancement of lncRNAs in tumor angiogenesis and anti-angiogenic therapy resistance and further discusses their potential clinical application. |
| first_indexed | 2024-12-12T19:42:40Z |
| format | Article |
| id | doaj.art-797c910e3e564985a1b129f94c132b87 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-12T19:42:40Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-797c910e3e564985a1b129f94c132b872022-12-22T00:14:10ZengElsevierMolecular Therapy: Nucleic Acids2162-25312022-06-0128397407The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancerJunxia Liu0Qinqiu Zhang1Daolu Yang2Fei Xie3Zhaoxia Wang4Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, ChinaCancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, ChinaCancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, ChinaCancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, ChinaCancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China; Corresponding author Zhaoxia Wang, Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China.It is well known that long non-coding RNAs (lncRNAs) play an important role in the regulation of tumor genesis and development. They can modulate gene expression of transcriptional regulation, epigenetic regulation of chromatin modification, and post-transcriptional regulation, thus influencing the biological behavior of tumors, such as cell proliferation, apoptosis, cell cycle, invasion, and migration. Tumor angiogenesis not only provides nutrients and helps excrete metabolites, but it also opens a pathway for tumor metastasis. Anti-angiogenic therapy has become one of the effective treatment methods for tumor. But its drug resistance leads to the limitation of clinical application. Recent studies have shown that lncRNAs are closely related to tumor angiogenesis and anti-angiogenic therapy resistance, which provides a new direction for tumor research. lncRNAs are expected to be new targets for tumor therapy. For the first time to our knowledge, this paper reviews advancement of lncRNAs in tumor angiogenesis and anti-angiogenic therapy resistance and further discusses their potential clinical application.http://www.sciencedirect.com/science/article/pii/S2162253122000610MT: non-coding RNAslong non-coding RNAsangiogenesisanti-angiogenic therapydrug resistancecancer stem cells |
| spellingShingle | Junxia Liu Qinqiu Zhang Daolu Yang Fei Xie Zhaoxia Wang The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer Molecular Therapy: Nucleic Acids MT: non-coding RNAs long non-coding RNAs angiogenesis anti-angiogenic therapy drug resistance cancer stem cells |
| title | The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer |
| title_full | The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer |
| title_fullStr | The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer |
| title_full_unstemmed | The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer |
| title_short | The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer |
| title_sort | role of long non coding rnas in angiogenesis and anti angiogenic therapy resistance in cancer |
| topic | MT: non-coding RNAs long non-coding RNAs angiogenesis anti-angiogenic therapy drug resistance cancer stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S2162253122000610 |
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