Motivation and Engagement during Visually Guided Behavior
Summary: Animal behavior is motivated by internal drives, such as thirst and hunger, generated in hypothalamic neurons that project widely to many brain areas. We find that water-restricted mice maintain stable, high-level contrast sensitivity and brief reaction time while performing a visual task,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124720312614 |
| _version_ | 1818324924140355584 |
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| author | Alexander V. Ortiz David Aziz Shaul Hestrin |
| author_facet | Alexander V. Ortiz David Aziz Shaul Hestrin |
| author_sort | Alexander V. Ortiz |
| collection | DOAJ |
| description | Summary: Animal behavior is motivated by internal drives, such as thirst and hunger, generated in hypothalamic neurons that project widely to many brain areas. We find that water-restricted mice maintain stable, high-level contrast sensitivity and brief reaction time while performing a visual task, but then abruptly stop and become disengaged. Mice consume a significant amount of water when freely provided in their home cage immediately after the task, indicating that disengagement does not reflect cessation of thirst. Neuronal responses of V1 neurons are reduced in the disengaged state, but pupil diameter does not decrease, suggesting that animals’ reduced level of arousal does not drive the transition to disengagement. Our findings indicate that satiation level alone does not have an instructive role in visually guided behavior and suggest that animals’ behavior is governed by cost-benefit analysis that can override thirst signals. |
| first_indexed | 2024-12-13T11:36:19Z |
| format | Article |
| id | doaj.art-797daf00dc29461292d8c3aae55996b1 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-13T11:36:19Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-797daf00dc29461292d8c3aae55996b12022-12-21T23:47:47ZengElsevierCell Reports2211-12472020-10-01333108272Motivation and Engagement during Visually Guided BehaviorAlexander V. Ortiz0David Aziz1Shaul Hestrin2Department of Comparative Medicine, Stanford School of Medicine, Stanford, CA 94305, USACollege of Optical Sciences, University of Arizona, Tucson, AZ 85721, USADepartment of Comparative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA; Corresponding authorSummary: Animal behavior is motivated by internal drives, such as thirst and hunger, generated in hypothalamic neurons that project widely to many brain areas. We find that water-restricted mice maintain stable, high-level contrast sensitivity and brief reaction time while performing a visual task, but then abruptly stop and become disengaged. Mice consume a significant amount of water when freely provided in their home cage immediately after the task, indicating that disengagement does not reflect cessation of thirst. Neuronal responses of V1 neurons are reduced in the disengaged state, but pupil diameter does not decrease, suggesting that animals’ reduced level of arousal does not drive the transition to disengagement. Our findings indicate that satiation level alone does not have an instructive role in visually guided behavior and suggest that animals’ behavior is governed by cost-benefit analysis that can override thirst signals.http://www.sciencedirect.com/science/article/pii/S2211124720312614visually guided behaviorcontrast sensitivityvisual cortexmotivationengagementthirst |
| spellingShingle | Alexander V. Ortiz David Aziz Shaul Hestrin Motivation and Engagement during Visually Guided Behavior Cell Reports visually guided behavior contrast sensitivity visual cortex motivation engagement thirst |
| title | Motivation and Engagement during Visually Guided Behavior |
| title_full | Motivation and Engagement during Visually Guided Behavior |
| title_fullStr | Motivation and Engagement during Visually Guided Behavior |
| title_full_unstemmed | Motivation and Engagement during Visually Guided Behavior |
| title_short | Motivation and Engagement during Visually Guided Behavior |
| title_sort | motivation and engagement during visually guided behavior |
| topic | visually guided behavior contrast sensitivity visual cortex motivation engagement thirst |
| url | http://www.sciencedirect.com/science/article/pii/S2211124720312614 |
| work_keys_str_mv | AT alexandervortiz motivationandengagementduringvisuallyguidedbehavior AT davidaziz motivationandengagementduringvisuallyguidedbehavior AT shaulhestrin motivationandengagementduringvisuallyguidedbehavior |