Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.
Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24116234/pdf/?tool=EBI |
| _version_ | 1818461451620188160 |
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| author | Danilo G Moriel Scott A Beatson Daniël J Wurpel Jeffrey Lipman Graeme R Nimmo David L Paterson Mark A Schembri |
| author_facet | Danilo G Moriel Scott A Beatson Daniël J Wurpel Jeffrey Lipman Graeme R Nimmo David L Paterson Mark A Schembri |
| author_sort | Danilo G Moriel |
| collection | DOAJ |
| description | Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the lack of a licensed vaccine, has translated into significant economic, logistic and health impacts to health care facilities. In this study, we combined reverse vaccinology and proteomics to identify surface-exposed and secreted antigens from A. baumannii. Using in silico prediction tools and comparative genome analysis in combination with in vitro proteomic approaches, we identified 42 antigens that could be used as potential vaccine targets. Considering the paucity of effective antibiotics available to treat multidrug-resistant A. baumannii infections, these vaccine targets may serve as a framework for the development of a broadly protective multi-component vaccine, an outcome that would have a major impact on the burden of A. baumannii infections in intensive care units across the globe. |
| first_indexed | 2024-12-14T23:46:21Z |
| format | Article |
| id | doaj.art-7980698f8b254a4ab4fe4bf20f936e86 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:46:21Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7980698f8b254a4ab4fe4bf20f936e862022-12-21T22:43:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7763110.1371/journal.pone.0077631Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.Danilo G MorielScott A BeatsonDaniël J WurpelJeffrey LipmanGraeme R NimmoDavid L PatersonMark A SchembriAcinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the lack of a licensed vaccine, has translated into significant economic, logistic and health impacts to health care facilities. In this study, we combined reverse vaccinology and proteomics to identify surface-exposed and secreted antigens from A. baumannii. Using in silico prediction tools and comparative genome analysis in combination with in vitro proteomic approaches, we identified 42 antigens that could be used as potential vaccine targets. Considering the paucity of effective antibiotics available to treat multidrug-resistant A. baumannii infections, these vaccine targets may serve as a framework for the development of a broadly protective multi-component vaccine, an outcome that would have a major impact on the burden of A. baumannii infections in intensive care units across the globe.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24116234/pdf/?tool=EBI |
| spellingShingle | Danilo G Moriel Scott A Beatson Daniël J Wurpel Jeffrey Lipman Graeme R Nimmo David L Paterson Mark A Schembri Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. PLoS ONE |
| title | Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. |
| title_full | Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. |
| title_fullStr | Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. |
| title_full_unstemmed | Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. |
| title_short | Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii. |
| title_sort | identification of novel vaccine candidates against multidrug resistant acinetobacter baumannii |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24116234/pdf/?tool=EBI |
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