Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients
The use of extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) has increased in the last decade. However, mortality remains high, and the complexity of ECMO requires individualized treatment. There are some biomarkers to monitor progression and predict clinical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/11/8/551 |
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| author | Gennaro Martucci Antonio Arcadipane Fabio Tuzzolino Giovanna Occhipinti Giovanna Panarello Claudia Carcione Alessandro Bertani Pier Giulio Conaldi Vitale Miceli |
| author_facet | Gennaro Martucci Antonio Arcadipane Fabio Tuzzolino Giovanna Occhipinti Giovanna Panarello Claudia Carcione Alessandro Bertani Pier Giulio Conaldi Vitale Miceli |
| author_sort | Gennaro Martucci |
| collection | DOAJ |
| description | The use of extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) has increased in the last decade. However, mortality remains high, and the complexity of ECMO requires individualized treatment. There are some biomarkers to monitor progression and predict clinical outcomes of ARDS. This project aims to advance the management of ARDS patients treated with ECMO by exploring miRNA expression in whole blood. The analysis was conducted on two groups with different length of ECMO: Group A (longer runs) and group B (shorter runs). We analyzed miRNAs before ECMO cannulation, and at 7 and 14 days of ECMO support. Our results showed that in the group B patients, 11 deregulated miRNAs were identified, and showed an opposite trend of expression compared to the group A patients. In silico analysis revealed that these 11 miRNAs were related to processes involved in the pathogenesis and evolution of ARDS. This scenario could represent homeostatic mechanisms by which, in ECMO responsive patients, pathways activated during ARDS progression are switched-off. Circulating miRNAs could represent promising biomarkers to monitor the evolution of ARDS under ECMO support. Further studies may shed light on this topic to improve a personalized approach in such a complex setting of patients. |
| first_indexed | 2024-03-10T08:37:08Z |
| format | Article |
| id | doaj.art-7981396389184cd4b5cd21f665129121 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T08:37:08Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-7981396389184cd4b5cd21f6651291212023-11-22T08:37:18ZengMDPI AGMembranes2077-03752021-07-0111855110.3390/membranes11080551Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS PatientsGennaro Martucci0Antonio Arcadipane1Fabio Tuzzolino2Giovanna Occhipinti3Giovanna Panarello4Claudia Carcione5Alessandro Bertani6Pier Giulio Conaldi7Vitale Miceli8Anesthesia and Intensive Care Department, IRCCS-ISMETT, 90127 Palermo, ItalyAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90127 Palermo, ItalyResearch Department, IRCCS-ISMETT, 90127 Palermo, ItalyAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90127 Palermo, ItalyAnesthesia and Intensive Care Department, IRCCS-ISMETT, 90127 Palermo, ItalyFondazione Ri.MED, 90127 Palermo, ItalyDivision of Thoracic Surgery and Lung Transplantation, Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT, 90127 Palermo, ItalyResearch Department, IRCCS-ISMETT, 90127 Palermo, ItalyResearch Department, IRCCS-ISMETT, 90127 Palermo, ItalyThe use of extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) has increased in the last decade. However, mortality remains high, and the complexity of ECMO requires individualized treatment. There are some biomarkers to monitor progression and predict clinical outcomes of ARDS. This project aims to advance the management of ARDS patients treated with ECMO by exploring miRNA expression in whole blood. The analysis was conducted on two groups with different length of ECMO: Group A (longer runs) and group B (shorter runs). We analyzed miRNAs before ECMO cannulation, and at 7 and 14 days of ECMO support. Our results showed that in the group B patients, 11 deregulated miRNAs were identified, and showed an opposite trend of expression compared to the group A patients. In silico analysis revealed that these 11 miRNAs were related to processes involved in the pathogenesis and evolution of ARDS. This scenario could represent homeostatic mechanisms by which, in ECMO responsive patients, pathways activated during ARDS progression are switched-off. Circulating miRNAs could represent promising biomarkers to monitor the evolution of ARDS under ECMO support. Further studies may shed light on this topic to improve a personalized approach in such a complex setting of patients.https://www.mdpi.com/2077-0375/11/8/551ARDSECMObiomarkersmiRNAs |
| spellingShingle | Gennaro Martucci Antonio Arcadipane Fabio Tuzzolino Giovanna Occhipinti Giovanna Panarello Claudia Carcione Alessandro Bertani Pier Giulio Conaldi Vitale Miceli Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients Membranes ARDS ECMO biomarkers miRNAs |
| title | Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients |
| title_full | Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients |
| title_fullStr | Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients |
| title_full_unstemmed | Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients |
| title_short | Circulating miRNAs as Promising Biomarkers to Evaluate ECMO Treatment Responses in ARDS Patients |
| title_sort | circulating mirnas as promising biomarkers to evaluate ecmo treatment responses in ards patients |
| topic | ARDS ECMO biomarkers miRNAs |
| url | https://www.mdpi.com/2077-0375/11/8/551 |
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