Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran
Background: Despite the effective pre- and post-exposure treatments, at least 60,000 deaths from rabies occur worldwide every year. Post-exposure treatment is considered as one of the most significant measures for preventing human deaths in exposed individuals. The 2-1-1 rabies post-exposure treatme...
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| Format: | Article |
| Language: | English |
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Pasteur Institute of Iran
2014-08-01
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| Series: | Vaccine Research |
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| Online Access: | http://vacres.pasteur.ac.ir/article-1-32-en.html |
| _version_ | 1828792785846665216 |
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| author | Pooneh Rahimi Mohammad Reza Shirzadi Firouzeh Farahtaj Vida Fallahian Jamal Sharifian Nader Howaizi Mansour Shamsipour Rouhollah Vahabpour |
| author_facet | Pooneh Rahimi Mohammad Reza Shirzadi Firouzeh Farahtaj Vida Fallahian Jamal Sharifian Nader Howaizi Mansour Shamsipour Rouhollah Vahabpour |
| author_sort | Pooneh Rahimi |
| collection | DOAJ |
| description | Background: Despite the effective pre- and post-exposure treatments, at least 60,000 deaths from rabies occur worldwide every year. Post-exposure treatment is considered as one of the most significant measures for preventing human deaths in exposed individuals. The 2-1-1 rabies post-exposure treatment schedule known as Zagreb regimen is an abbreviated immunization plan in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0 and at one site on days 7 and 21. Objectives: In this study the efficacy of rabies vaccine administration under Zagreb regimen in an Iranian group of patients attending Pasteur Institute of Iran was evaluated. Methods: Rabies neutralizing antibody titer was measured in 75 serum samples collected from 25 volunteers receiving post exposure treatment by rapid fluorescent focus inhibition test (RFFIT), and ELISA. Results: All patients were negative for rabies antibody in both ELISA and FRRIT tests on day 0 . A satisfactory rabies virus antibody response with the titer of ≥0.5 IU/ml was detected in all patients on day 21 and two weeks after the completion of vaccination (day 35). Conclusions: Rabies immunization with rabies Vero-cell vaccine (PVRV) under the 2-1-1 schedule (Zagreb regimen) could result in an adequate immune response without any adverse effect. However a more comprehensive comparative study is underway to confirm these findings . Vac Res , 2014, 1 (1): 26-28 |
| first_indexed | 2024-12-12T03:14:42Z |
| format | Article |
| id | doaj.art-79852b62c6814a4493431e82a39261f6 |
| institution | Directory Open Access Journal |
| issn | 2383-2819 2423-4923 |
| language | English |
| last_indexed | 2024-12-12T03:14:42Z |
| publishDate | 2014-08-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Vaccine Research |
| spelling | doaj.art-79852b62c6814a4493431e82a39261f62022-12-22T00:40:19ZengPasteur Institute of IranVaccine Research2383-28192423-49232014-08-01112527Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in IranPooneh Rahimi0Mohammad Reza Shirzadi1Firouzeh Farahtaj2Vida Fallahian3Jamal Sharifian4Nader Howaizi5Mansour Shamsipour6Rouhollah Vahabpour7 Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran Center of Disease Control (CDC), Ministry of Health, Tehran, Iran WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran Department of Vaccination, Rabies post-exposure prophylaxis, Pasteur Institute of Iran, Tehran, Iran Center of Disease Control (CDC), Ministry of Health, Tehran, Iran WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran Background: Despite the effective pre- and post-exposure treatments, at least 60,000 deaths from rabies occur worldwide every year. Post-exposure treatment is considered as one of the most significant measures for preventing human deaths in exposed individuals. The 2-1-1 rabies post-exposure treatment schedule known as Zagreb regimen is an abbreviated immunization plan in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0 and at one site on days 7 and 21. Objectives: In this study the efficacy of rabies vaccine administration under Zagreb regimen in an Iranian group of patients attending Pasteur Institute of Iran was evaluated. Methods: Rabies neutralizing antibody titer was measured in 75 serum samples collected from 25 volunteers receiving post exposure treatment by rapid fluorescent focus inhibition test (RFFIT), and ELISA. Results: All patients were negative for rabies antibody in both ELISA and FRRIT tests on day 0 . A satisfactory rabies virus antibody response with the titer of ≥0.5 IU/ml was detected in all patients on day 21 and two weeks after the completion of vaccination (day 35). Conclusions: Rabies immunization with rabies Vero-cell vaccine (PVRV) under the 2-1-1 schedule (Zagreb regimen) could result in an adequate immune response without any adverse effect. However a more comprehensive comparative study is underway to confirm these findings . Vac Res , 2014, 1 (1): 26-28http://vacres.pasteur.ac.ir/article-1-32-en.htmlzagreb regimenpvrvrabies vaccinespost-exposure prophylaxis |
| spellingShingle | Pooneh Rahimi Mohammad Reza Shirzadi Firouzeh Farahtaj Vida Fallahian Jamal Sharifian Nader Howaizi Mansour Shamsipour Rouhollah Vahabpour Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran Vaccine Research zagreb regimen pvrv rabies vaccines post-exposure prophylaxis |
| title | Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran |
| title_full | Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran |
| title_fullStr | Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran |
| title_full_unstemmed | Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran |
| title_short | Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran |
| title_sort | efficacy of purified vero cell rabies vaccine pvrv under the zagreb regimen in iran |
| topic | zagreb regimen pvrv rabies vaccines post-exposure prophylaxis |
| url | http://vacres.pasteur.ac.ir/article-1-32-en.html |
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