Diagnostic and Prognostic Performance of Neurofilaments in ALS
There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.01167/full |
| _version_ | 1811270374847938560 |
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| author | Koen Poesen Koen Poesen Philip Van Damme Philip Van Damme |
| author_facet | Koen Poesen Koen Poesen Philip Van Damme Philip Van Damme |
| author_sort | Koen Poesen |
| collection | DOAJ |
| description | There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal fluid and blood, as biomarker for ALS. The most widely studied neurofilament subunits are neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH). Neurofilament levels are reflecting neuronal injury and therefore potentially of value in ALS and other neurological disorders. In this mini-review, we summarize and discuss the available evidence about neurofilaments as diagnostic and prognostic biomarker for human ALS. |
| first_indexed | 2024-04-12T22:00:46Z |
| format | Article |
| id | doaj.art-79861cdd15ba44a1acb63b1e494de58f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T22:00:46Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-79861cdd15ba44a1acb63b1e494de58f2022-12-22T03:15:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-01-01910.3389/fneur.2018.01167433959Diagnostic and Prognostic Performance of Neurofilaments in ALSKoen Poesen0Koen Poesen1Philip Van Damme2Philip Van Damme3Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research, KU Leuven, Leuven, BelgiumLaboratory Medicine, University Hospitals Leuven, Leuven, BelgiumLaboratory of Neurobiology, Department of Neurosciences, KU Leuven and Center for Brain & Disease Research VIB Leuven, Leuven, BelgiumDepartment of Neurology, Neuromuscular Reference Centre, University Hospitals Leuven, Leuven, BelgiumThere is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal fluid and blood, as biomarker for ALS. The most widely studied neurofilament subunits are neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH). Neurofilament levels are reflecting neuronal injury and therefore potentially of value in ALS and other neurological disorders. In this mini-review, we summarize and discuss the available evidence about neurofilaments as diagnostic and prognostic biomarker for human ALS.https://www.frontiersin.org/article/10.3389/fneur.2018.01167/fullamyotrophic lateral sclerosisfrontotemporal dementianeurofilamentcerebrospinal fluidserumplasma |
| spellingShingle | Koen Poesen Koen Poesen Philip Van Damme Philip Van Damme Diagnostic and Prognostic Performance of Neurofilaments in ALS Frontiers in Neurology amyotrophic lateral sclerosis frontotemporal dementia neurofilament cerebrospinal fluid serum plasma |
| title | Diagnostic and Prognostic Performance of Neurofilaments in ALS |
| title_full | Diagnostic and Prognostic Performance of Neurofilaments in ALS |
| title_fullStr | Diagnostic and Prognostic Performance of Neurofilaments in ALS |
| title_full_unstemmed | Diagnostic and Prognostic Performance of Neurofilaments in ALS |
| title_short | Diagnostic and Prognostic Performance of Neurofilaments in ALS |
| title_sort | diagnostic and prognostic performance of neurofilaments in als |
| topic | amyotrophic lateral sclerosis frontotemporal dementia neurofilament cerebrospinal fluid serum plasma |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.01167/full |
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