Stress Activated MAP Kinases and Cyclin-Dependent Kinase 5 Mediate Nuclear Translocation of Nrf2 via Hsp90α-Pin1-Dynein Motor Transport Machinery

Stress Activated MAP Kinases and Cyclin-Dependent Kinase 5 Mediate Nuclear Translocation of Nrf2 via Hsp90α-Pin1-Dynein Motor Transport Machinery

Non-lethal low levels of oxidative stress leads to rapid activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which upregulates the expression of genes important for detoxification, glutathione synthesis, and defense against oxidative damage. Stress-activated MAP kinases...

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Bibliographic Details
Main Authors: Tetsuro Ishii, Eiji Warabi, Giovanni E. Mann
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
Nrf2
Hsp90
ERK
JNK
Cdk5
Pin1
Online Access:https://www.mdpi.com/2076-3921/12/2/274

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