The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia
Multiple projection neurons are often activated to initiate behavior. A question that then arises is, what is the unique functional role of each neuron activated? We address this issue in the feeding system of Aplysia. Previous experiments identified a projection neuron [cerebral buccal interneuron...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2021.685222/full |
| _version_ | 1818664108157829120 |
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| author | Colin G. Evans Michael A. Barry Jian Jing Jian Jing Matthew H. Perkins Klaudiusz R. Weiss Elizabeth C. Cropper |
| author_facet | Colin G. Evans Michael A. Barry Jian Jing Jian Jing Matthew H. Perkins Klaudiusz R. Weiss Elizabeth C. Cropper |
| author_sort | Colin G. Evans |
| collection | DOAJ |
| description | Multiple projection neurons are often activated to initiate behavior. A question that then arises is, what is the unique functional role of each neuron activated? We address this issue in the feeding system of Aplysia. Previous experiments identified a projection neuron [cerebral buccal interneuron 2 (CBI-2)] that can trigger ingestive motor programs but only after it is repeatedly stimulated, i.e., initial programs are poorly defined. As CBI-2 stimulation continues, programs become progressively more ingestive (repetition priming occurs). This priming results, at least in part, from persistent actions of peptide cotransmitters released from CBI-2. We now show that in some preparations repetition priming does not occur. There is no clear seasonal effect; priming and non-priming preparations are encountered throughout the year. CBI-2 is electrically coupled to a second projection neuron, cerebral buccal interneuron 3 (CBI-3). In preparations in which priming does not occur, we show that ingestive activity is generated when CBI-2 and CBI-3 are coactivated. Programs are immediately ingestive, i.e., priming is not necessary, and a persistent state is not induced. Our data suggest that dynamic changes in the configuration of activity can vary and be determined by the complement of projection neurons that trigger activity. |
| first_indexed | 2024-12-17T05:27:30Z |
| format | Article |
| id | doaj.art-798ac011388b4f538c4219413f29c45e |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-17T05:27:30Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-798ac011388b4f538c4219413f29c45e2022-12-21T22:01:50ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102021-06-011510.3389/fncir.2021.685222685222The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in AplysiaColin G. Evans0Michael A. Barry1Jian Jing2Jian Jing3Matthew H. Perkins4Klaudiusz R. Weiss5Elizabeth C. Cropper6Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesState Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, ChinaDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesMultiple projection neurons are often activated to initiate behavior. A question that then arises is, what is the unique functional role of each neuron activated? We address this issue in the feeding system of Aplysia. Previous experiments identified a projection neuron [cerebral buccal interneuron 2 (CBI-2)] that can trigger ingestive motor programs but only after it is repeatedly stimulated, i.e., initial programs are poorly defined. As CBI-2 stimulation continues, programs become progressively more ingestive (repetition priming occurs). This priming results, at least in part, from persistent actions of peptide cotransmitters released from CBI-2. We now show that in some preparations repetition priming does not occur. There is no clear seasonal effect; priming and non-priming preparations are encountered throughout the year. CBI-2 is electrically coupled to a second projection neuron, cerebral buccal interneuron 3 (CBI-3). In preparations in which priming does not occur, we show that ingestive activity is generated when CBI-2 and CBI-3 are coactivated. Programs are immediately ingestive, i.e., priming is not necessary, and a persistent state is not induced. Our data suggest that dynamic changes in the configuration of activity can vary and be determined by the complement of projection neurons that trigger activity.https://www.frontiersin.org/articles/10.3389/fncir.2021.685222/fullmolluscfeedingAplysiacentral pattern generatorscommand neuron |
| spellingShingle | Colin G. Evans Michael A. Barry Jian Jing Jian Jing Matthew H. Perkins Klaudiusz R. Weiss Elizabeth C. Cropper The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia Frontiers in Neural Circuits mollusc feeding Aplysia central pattern generators command neuron |
| title | The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia |
| title_full | The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia |
| title_fullStr | The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia |
| title_full_unstemmed | The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia |
| title_short | The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia |
| title_sort | complement of projection neurons activated determines the type of feeding motor program in aplysia |
| topic | mollusc feeding Aplysia central pattern generators command neuron |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2021.685222/full |
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