Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care
Abstract Aims To examine the association of the screening frequency of estimated glomerular filtration rate (eGFR) with the substantial reduction in eGFR (≥ 25%) among type 2 diabetes (T2D) patients with normal (eGFR≥60 ml/min/1.73 m2) and impaired kidney function (eGFR< 60 ml/min/1.73 m2). Metho...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-022-02979-1 |
| _version_ | 1828155935303925760 |
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| author | Henry Sundqvist Eveliina Heikkala Jari Jokelainen Giuseppina Russo Ilona Mikkola Maria Hagnäs |
| author_facet | Henry Sundqvist Eveliina Heikkala Jari Jokelainen Giuseppina Russo Ilona Mikkola Maria Hagnäs |
| author_sort | Henry Sundqvist |
| collection | DOAJ |
| description | Abstract Aims To examine the association of the screening frequency of estimated glomerular filtration rate (eGFR) with the substantial reduction in eGFR (≥ 25%) among type 2 diabetes (T2D) patients with normal (eGFR≥60 ml/min/1.73 m2) and impaired kidney function (eGFR< 60 ml/min/1.73 m2). Methods A longitudinal study involving 5104 T2D patients with follow-up period of 6.8 years (1.9 SD) were treated at the Rovaniemi Health Center, Rovaniemi, Finland during 2011–2019. The association between the screening frequency of eGFR (yearly vs. non-yearly) and the substantial reduction in eGFR was studied with logistical models and adjusted with biochemical variables and preventive medications. Results Among the T2D patients with normal kidney function, non-yearly eGFR screening was significantly associated with substantial eGFR reduction in both unadjusted (odds ratio [OR] 3.29, 95% confidence interval [CI] 2.54–4.33) and adjusted models (OR 2.06, 95% CI 1.21–3.73) compared with yearly screening frequency. In the group of patients with impaired kidney function in the unadjusted model, non-yearly eGFR screening was significantly associated with substantial eGFR reduction (OR 2.38, 95% CI 1.30–4.73), but became non-significant after adjustments (OR 1.89, 95% CI 0.61–7.21). Conclusions This study underscores the role of regular eGFR screening in the prevention of kidney function decline. |
| first_indexed | 2024-04-11T23:01:52Z |
| format | Article |
| id | doaj.art-798ae32d1a8d4bffaf0f948c06479bc5 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-11T23:01:52Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-798ae32d1a8d4bffaf0f948c06479bc52022-12-22T03:58:07ZengBMCBMC Nephrology1471-23692022-11-012311810.1186/s12882-022-02979-1Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health careHenry Sundqvist0Eveliina Heikkala1Jari Jokelainen2Giuseppina Russo3Ilona Mikkola4Maria Hagnäs5Rovaniemi Health CenterRovaniemi Health CenterCenter for Life Course Health Research, University of OuluDepartment of Clinical and Experimental Medicine, University of MessinaRovaniemi Health CenterRovaniemi Health CenterAbstract Aims To examine the association of the screening frequency of estimated glomerular filtration rate (eGFR) with the substantial reduction in eGFR (≥ 25%) among type 2 diabetes (T2D) patients with normal (eGFR≥60 ml/min/1.73 m2) and impaired kidney function (eGFR< 60 ml/min/1.73 m2). Methods A longitudinal study involving 5104 T2D patients with follow-up period of 6.8 years (1.9 SD) were treated at the Rovaniemi Health Center, Rovaniemi, Finland during 2011–2019. The association between the screening frequency of eGFR (yearly vs. non-yearly) and the substantial reduction in eGFR was studied with logistical models and adjusted with biochemical variables and preventive medications. Results Among the T2D patients with normal kidney function, non-yearly eGFR screening was significantly associated with substantial eGFR reduction in both unadjusted (odds ratio [OR] 3.29, 95% confidence interval [CI] 2.54–4.33) and adjusted models (OR 2.06, 95% CI 1.21–3.73) compared with yearly screening frequency. In the group of patients with impaired kidney function in the unadjusted model, non-yearly eGFR screening was significantly associated with substantial eGFR reduction (OR 2.38, 95% CI 1.30–4.73), but became non-significant after adjustments (OR 1.89, 95% CI 0.61–7.21). Conclusions This study underscores the role of regular eGFR screening in the prevention of kidney function decline.https://doi.org/10.1186/s12882-022-02979-1Kidney FunctionPrimary Health CareScreening FrequencyType 2 Diabetes |
| spellingShingle | Henry Sundqvist Eveliina Heikkala Jari Jokelainen Giuseppina Russo Ilona Mikkola Maria Hagnäs Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care BMC Nephrology Kidney Function Primary Health Care Screening Frequency Type 2 Diabetes |
| title | Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care |
| title_full | Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care |
| title_fullStr | Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care |
| title_full_unstemmed | Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care |
| title_short | Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care |
| title_sort | association of renal function screening frequency with renal function decline in patients with type 2 diabetes a real world study in primary health care |
| topic | Kidney Function Primary Health Care Screening Frequency Type 2 Diabetes |
| url | https://doi.org/10.1186/s12882-022-02979-1 |
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