The Perioperative Correction of Homeostasis in Obstructive Jaundice
Obstructive jaundice is a common abdominal abnormality showing a high incidence of postoperative hepatic failure associated with progressive endotoxicosis and metabolic disturbances. Objective: to evaluate the efficacy of the infusion agent Sterofundin-G-5 in the pre- and postoperative correction of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2008-04-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/792 |
| _version_ | 1797874346274848768 |
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| author | A. Yu. Yakovlev G. A. Boyarinov S. B. Foshina R. M. Zaitsev N. V. Zarechnova |
| author_facet | A. Yu. Yakovlev G. A. Boyarinov S. B. Foshina R. M. Zaitsev N. V. Zarechnova |
| author_sort | A. Yu. Yakovlev |
| collection | DOAJ |
| description | Obstructive jaundice is a common abdominal abnormality showing a high incidence of postoperative hepatic failure associated with progressive endotoxicosis and metabolic disturbances. Objective: to evaluate the efficacy of the infusion agent Sterofundin-G-5 in the pre- and postoperative correction of metabolic disturbances and endotoxicosis in patients with obstructive jaundice. Subjects and methods. Fifty-three patients divided into 3 comparable patients receiving the equal volume of infusion therapy (60 ml/kg/day) were examined. Prior to and following surgery, Group 1 patients received Ringer’s solution and 10% glucose solution in a 1:1 ratio. In Group 2, the preoperative preparation did not differ from that in Group 1; Sterofundin-G-5 was postoperatively used. In Group 3, pre- and postoperative infusion was made using Sterofundin-G-5. Results. The effect of malate as a component of Sterofundin-G-5 on metabolic parameters, lipid peroxidation/antioxidative system, bilirubinemia, enzymemia, and endotoxicosis was investigated. Preoperative preparation using Sterofundin-G-5 was found to have a suppressing effect on the progression of detected abnormalities of the study parameters. It was established that it was necessary to combine pre- and postoperative administration of Sterofundin-G-5 for the prevention of the detected abnormalities of the study systems and for the reduction of the time of their postoperative compensation. Key words: obstructive jaundice, malate, metabolism, bilirubin, enzymemia, endotoxicosis. |
| first_indexed | 2024-04-10T01:30:34Z |
| format | Article |
| id | doaj.art-798c4973099c4d86a0886fc86e50938f |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:30:34Z |
| publishDate | 2008-04-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-798c4973099c4d86a0886fc86e50938f2023-03-13T09:32:48ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102008-04-014210.15360/1813-9779-2008-2-58792The Perioperative Correction of Homeostasis in Obstructive JaundiceA. Yu. YakovlevG. A. BoyarinovS. B. FoshinaR. M. ZaitsevN. V. ZarechnovaObstructive jaundice is a common abdominal abnormality showing a high incidence of postoperative hepatic failure associated with progressive endotoxicosis and metabolic disturbances. Objective: to evaluate the efficacy of the infusion agent Sterofundin-G-5 in the pre- and postoperative correction of metabolic disturbances and endotoxicosis in patients with obstructive jaundice. Subjects and methods. Fifty-three patients divided into 3 comparable patients receiving the equal volume of infusion therapy (60 ml/kg/day) were examined. Prior to and following surgery, Group 1 patients received Ringer’s solution and 10% glucose solution in a 1:1 ratio. In Group 2, the preoperative preparation did not differ from that in Group 1; Sterofundin-G-5 was postoperatively used. In Group 3, pre- and postoperative infusion was made using Sterofundin-G-5. Results. The effect of malate as a component of Sterofundin-G-5 on metabolic parameters, lipid peroxidation/antioxidative system, bilirubinemia, enzymemia, and endotoxicosis was investigated. Preoperative preparation using Sterofundin-G-5 was found to have a suppressing effect on the progression of detected abnormalities of the study parameters. It was established that it was necessary to combine pre- and postoperative administration of Sterofundin-G-5 for the prevention of the detected abnormalities of the study systems and for the reduction of the time of their postoperative compensation. Key words: obstructive jaundice, malate, metabolism, bilirubin, enzymemia, endotoxicosis.https://www.reanimatology.com/rmt/article/view/792 |
| spellingShingle | A. Yu. Yakovlev G. A. Boyarinov S. B. Foshina R. M. Zaitsev N. V. Zarechnova The Perioperative Correction of Homeostasis in Obstructive Jaundice Общая реаниматология |
| title | The Perioperative Correction of Homeostasis in Obstructive Jaundice |
| title_full | The Perioperative Correction of Homeostasis in Obstructive Jaundice |
| title_fullStr | The Perioperative Correction of Homeostasis in Obstructive Jaundice |
| title_full_unstemmed | The Perioperative Correction of Homeostasis in Obstructive Jaundice |
| title_short | The Perioperative Correction of Homeostasis in Obstructive Jaundice |
| title_sort | perioperative correction of homeostasis in obstructive jaundice |
| url | https://www.reanimatology.com/rmt/article/view/792 |
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