Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection
Shigella typically causes gastrointestinal infections, and extra-intestinal manifestations are rare. We report the first known case of pyogenic cervical spondylitis co-infected with Escherichia coli and Shigella flexneri, highlighting the diagnostic challenges and clinical implications. A 53-year-ol...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250924000064 |
| _version_ | 1797261844098842624 |
|---|---|
| author | Jiafeng Zhang Yaoting Liu Hongkun Wu Lin Zhou |
| author_facet | Jiafeng Zhang Yaoting Liu Hongkun Wu Lin Zhou |
| author_sort | Jiafeng Zhang |
| collection | DOAJ |
| description | Shigella typically causes gastrointestinal infections, and extra-intestinal manifestations are rare. We report the first known case of pyogenic cervical spondylitis co-infected with Escherichia coli and Shigella flexneri, highlighting the diagnostic challenges and clinical implications. A 53-year-old woman presented with neck pain for one month. MRI revealed C6 and C7 vertebrae abscesses. The patient underwent anterior cervical debridement and bone-graft fusion. Intraoperative pus culture grew Escherichia coli, while metagenomic next-generation sequencing detected both Escherichia coli and Shigella species. Intravenous imipenem 500 mg every 6 h was administered, leading to full wound healing at a 6-month follow-up. This case emphasizes the importance of considering Shigella infection in the differential diagnosis of pyogenic spondylitis and demonstrates the utility of a multi-pronged diagnostic approach. |
| first_indexed | 2024-03-08T06:56:00Z |
| format | Article |
| id | doaj.art-798e45ae1e454cb7a8c0004fc7691f1c |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-04-24T23:47:40Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-798e45ae1e454cb7a8c0004fc7691f1c2024-03-15T04:43:31ZengElsevierIDCases2214-25092024-01-0135e01930Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infectionJiafeng Zhang0Yaoting Liu1Hongkun Wu2Lin Zhou3Department of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, PR ChinaDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, PR ChinaDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, PR ChinaCorresponding author.; Department of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, PR ChinaShigella typically causes gastrointestinal infections, and extra-intestinal manifestations are rare. We report the first known case of pyogenic cervical spondylitis co-infected with Escherichia coli and Shigella flexneri, highlighting the diagnostic challenges and clinical implications. A 53-year-old woman presented with neck pain for one month. MRI revealed C6 and C7 vertebrae abscesses. The patient underwent anterior cervical debridement and bone-graft fusion. Intraoperative pus culture grew Escherichia coli, while metagenomic next-generation sequencing detected both Escherichia coli and Shigella species. Intravenous imipenem 500 mg every 6 h was administered, leading to full wound healing at a 6-month follow-up. This case emphasizes the importance of considering Shigella infection in the differential diagnosis of pyogenic spondylitis and demonstrates the utility of a multi-pronged diagnostic approach.http://www.sciencedirect.com/science/article/pii/S2214250924000064Escherichia coliShigella flexneriPyogenic cervical spondylitisMetagenomic next-generation sequencingCase report |
| spellingShingle | Jiafeng Zhang Yaoting Liu Hongkun Wu Lin Zhou Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection IDCases Escherichia coli Shigella flexneri Pyogenic cervical spondylitis Metagenomic next-generation sequencing Case report |
| title | Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection |
| title_full | Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection |
| title_fullStr | Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection |
| title_full_unstemmed | Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection |
| title_short | Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused by Escherichia coli and Shigella flexneri infection |
| title_sort | is shigella an under recognized pathogen a case of pyogenic cervical spondylitis caused by escherichia coli and shigella flexneri infection |
| topic | Escherichia coli Shigella flexneri Pyogenic cervical spondylitis Metagenomic next-generation sequencing Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2214250924000064 |
| work_keys_str_mv | AT jiafengzhang isshigellaanunderrecognizedpathogenacaseofpyogeniccervicalspondylitiscausedbyescherichiacoliandshigellaflexneriinfection AT yaotingliu isshigellaanunderrecognizedpathogenacaseofpyogeniccervicalspondylitiscausedbyescherichiacoliandshigellaflexneriinfection AT hongkunwu isshigellaanunderrecognizedpathogenacaseofpyogeniccervicalspondylitiscausedbyescherichiacoliandshigellaflexneriinfection AT linzhou isshigellaanunderrecognizedpathogenacaseofpyogeniccervicalspondylitiscausedbyescherichiacoliandshigellaflexneriinfection |