Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Insulin-like growth factor 1 (IGF1) regulates growth and differentiation. Here, authors report the atomic structure of the ternary complex (IGF1/IGF-binding protein3/acid labile subunit) and its assembly/disassembly mechanism for IGF bioavailability.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32214-2 |
| _version_ | 1818163001615712256 |
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| author | Hyojin Kim Yaoyao Fu Ho Jeong Hong Seong-Gyu Lee Dong Sun Lee Ho Min Kim |
| author_facet | Hyojin Kim Yaoyao Fu Ho Jeong Hong Seong-Gyu Lee Dong Sun Lee Ho Min Kim |
| author_sort | Hyojin Kim |
| collection | DOAJ |
| description | Insulin-like growth factor 1 (IGF1) regulates growth and differentiation. Here, authors report the atomic structure of the ternary complex (IGF1/IGF-binding protein3/acid labile subunit) and its assembly/disassembly mechanism for IGF bioavailability. |
| first_indexed | 2024-12-11T16:42:37Z |
| format | Article |
| id | doaj.art-798ec222fcee4dcbb60c66cd122017f6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T16:42:37Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-798ec222fcee4dcbb60c66cd122017f62022-12-22T00:58:18ZengNature PortfolioNature Communications2041-17232022-07-0113111710.1038/s41467-022-32214-2Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complexHyojin Kim0Yaoyao Fu1Ho Jeong Hong2Seong-Gyu Lee3Dong Sun Lee4Ho Min Kim5Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Center for Biomolecular & Cellular Structure, IBSCenter for Biomolecular & Cellular Structure, IBSCenter for Biomolecular & Cellular Structure, IBSCenter for Biomolecular & Cellular Structure, IBSGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Insulin-like growth factor 1 (IGF1) regulates growth and differentiation. Here, authors report the atomic structure of the ternary complex (IGF1/IGF-binding protein3/acid labile subunit) and its assembly/disassembly mechanism for IGF bioavailability.https://doi.org/10.1038/s41467-022-32214-2 |
| spellingShingle | Hyojin Kim Yaoyao Fu Ho Jeong Hong Seong-Gyu Lee Dong Sun Lee Ho Min Kim Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nature Communications |
| title | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex |
| title_full | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex |
| title_fullStr | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex |
| title_full_unstemmed | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex |
| title_short | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex |
| title_sort | structural basis for assembly and disassembly of the igf igfbp als ternary complex |
| url | https://doi.org/10.1038/s41467-022-32214-2 |
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