Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Insulin-like growth factor 1 (IGF1) regulates growth and differentiation. Here, authors report the atomic structure of the ternary complex (IGF1/IGF-binding protein3/acid labile subunit) and its assembly/disassembly mechanism for IGF bioavailability.

Bibliographic Details
Main Authors: Hyojin Kim, Yaoyao Fu, Ho Jeong Hong, Seong-Gyu Lee, Dong Sun Lee, Ho Min Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32214-2

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