Histopathological audit of renal biopsy in Nepalese children: two center experience
<p><strong>Background:</strong> Renal biopsy is an invaluable tool which provides histopathological description of renal disease in terms of severity of lesion and helps in formulating the long term plan. However such studies with histopathological description of renal biopsy among...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2018-04-01
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| Series: | Journal of Pathology of Nepal |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/19443 |
| _version_ | 1828836182248652800 |
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| author | Devendra Shrestha Ajaya Kumar Dhakal Nabin Bahadur Basnet Shiva Raj KC Rishi Kumar Kafle |
| author_facet | Devendra Shrestha Ajaya Kumar Dhakal Nabin Bahadur Basnet Shiva Raj KC Rishi Kumar Kafle |
| author_sort | Devendra Shrestha |
| collection | DOAJ |
| description | <p><strong>Background:</strong> Renal biopsy is an invaluable tool which provides histopathological description of renal disease in terms of severity of lesion and helps in formulating the long term plan. However such studies with histopathological description of renal biopsy among Nepalese children are scarce.</p><p><strong>Material and Methods: </strong>This was a retrospective study conducted among all children aged less than 18 years who underwent renal biopsy at two tertiary centers in Nepal between July 2015 and December 2017.</p><p><strong>Results: </strong>All 72 renal biopsies were done with Bard 18G spring loaded gun. Nephrotic syndrome and mixed nephritic-nephrotic features were the commonest indications for renal biopsy. IgA nephropathy was the most frequent histopathological diagnosis (20.8%) which was mainly observed in children of age group 11-18 years followed by minimal change disease (16.7%) and diffuse proliferative glomerulonephritis (16.7%). Majority of children with recurrent gross hematuria (6/7) or mixed nephritic-nephrotic features (6/8) had IgA nephropathy. Focal segmental glomerulosclerosis (6/8) was commonest in children with steroid resistant nephrotic syndrome and nephrotic syndrome with atypical features. Majority of children (10/12) with diffuse proliferative glomerulonephritis had features of poststreptococcal glomerulonephritis and 6/12 had crescents in glomeruli. Lupus nephritis (13.9%) was the commonest secondary cause of glomerular pathology and was observed predominantly in 11-18 years age.</p><p><strong>Conclusion: </strong>Renal biopsy is safe and not associated with clinically significant complications. Nephrotic syndrome was the commonest indication for renal biopsy and minimal change disease predominated. IgA nephropathy was the commonest histological diagnosis overall, as well as in children who presented with recurrent gross hematuria or mixed nephritic-nephrotic features.</p> |
| first_indexed | 2024-12-12T18:15:56Z |
| format | Article |
| id | doaj.art-798eef651f0f41f6942449dd5f06e8d9 |
| institution | Directory Open Access Journal |
| issn | 2091-0797 2091-0908 |
| language | English |
| last_indexed | 2024-12-12T18:15:56Z |
| publishDate | 2018-04-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj.art-798eef651f0f41f6942449dd5f06e8d92022-12-22T00:16:15ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082018-04-01811244125010.3126/jpn.v8i1.1944315109Histopathological audit of renal biopsy in Nepalese children: two center experienceDevendra Shrestha0Ajaya Kumar Dhakal1Nabin Bahadur Basnet2Shiva Raj KC3Rishi Kumar Kafle4KIST Medical College and Teaching HospitalKIST Medical College and Teaching HospitalSumeru Kidney HospitalKIST Medical College and Teaching HospitalSumeru Kidney Hospital<p><strong>Background:</strong> Renal biopsy is an invaluable tool which provides histopathological description of renal disease in terms of severity of lesion and helps in formulating the long term plan. However such studies with histopathological description of renal biopsy among Nepalese children are scarce.</p><p><strong>Material and Methods: </strong>This was a retrospective study conducted among all children aged less than 18 years who underwent renal biopsy at two tertiary centers in Nepal between July 2015 and December 2017.</p><p><strong>Results: </strong>All 72 renal biopsies were done with Bard 18G spring loaded gun. Nephrotic syndrome and mixed nephritic-nephrotic features were the commonest indications for renal biopsy. IgA nephropathy was the most frequent histopathological diagnosis (20.8%) which was mainly observed in children of age group 11-18 years followed by minimal change disease (16.7%) and diffuse proliferative glomerulonephritis (16.7%). Majority of children with recurrent gross hematuria (6/7) or mixed nephritic-nephrotic features (6/8) had IgA nephropathy. Focal segmental glomerulosclerosis (6/8) was commonest in children with steroid resistant nephrotic syndrome and nephrotic syndrome with atypical features. Majority of children (10/12) with diffuse proliferative glomerulonephritis had features of poststreptococcal glomerulonephritis and 6/12 had crescents in glomeruli. Lupus nephritis (13.9%) was the commonest secondary cause of glomerular pathology and was observed predominantly in 11-18 years age.</p><p><strong>Conclusion: </strong>Renal biopsy is safe and not associated with clinically significant complications. Nephrotic syndrome was the commonest indication for renal biopsy and minimal change disease predominated. IgA nephropathy was the commonest histological diagnosis overall, as well as in children who presented with recurrent gross hematuria or mixed nephritic-nephrotic features.</p>https://www.nepjol.info/index.php/JPN/article/view/19443HematuriaHistopathologyIgA nephropathyKidneyNephroticRenal |
| spellingShingle | Devendra Shrestha Ajaya Kumar Dhakal Nabin Bahadur Basnet Shiva Raj KC Rishi Kumar Kafle Histopathological audit of renal biopsy in Nepalese children: two center experience Journal of Pathology of Nepal Hematuria Histopathology IgA nephropathy Kidney Nephrotic Renal |
| title | Histopathological audit of renal biopsy in Nepalese children: two center experience |
| title_full | Histopathological audit of renal biopsy in Nepalese children: two center experience |
| title_fullStr | Histopathological audit of renal biopsy in Nepalese children: two center experience |
| title_full_unstemmed | Histopathological audit of renal biopsy in Nepalese children: two center experience |
| title_short | Histopathological audit of renal biopsy in Nepalese children: two center experience |
| title_sort | histopathological audit of renal biopsy in nepalese children two center experience |
| topic | Hematuria Histopathology IgA nephropathy Kidney Nephrotic Renal |
| url | https://www.nepjol.info/index.php/JPN/article/view/19443 |
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