Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases
Adhesion G protein-coupled receptors (aGPCRs) are the second largest diverse group within the GPCR superfamily, which play critical roles in many physiological and pathological processes through cell–cell and cell–extracellular matrix interactions. The adhesion GPCR Adgrg6, also known as GPR126, is...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223000685 |
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| author | Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong |
| author_facet | Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong |
| author_sort | Qi Li |
| collection | DOAJ |
| description | Adhesion G protein-coupled receptors (aGPCRs) are the second largest diverse group within the GPCR superfamily, which play critical roles in many physiological and pathological processes through cell–cell and cell–extracellular matrix interactions. The adhesion GPCR Adgrg6, also known as GPR126, is one of the better-characterized aGPCRs. GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals. Current studies have extended our understanding of GPR126-mediated roles during development and in human diseases. In this review, we highlighted these recent advances in GPR126 in expression profile, molecular structure, ligand–receptor interactions, and associated physiological and pathological functions in development and diseases. |
| first_indexed | 2024-03-12T15:18:57Z |
| format | Article |
| id | doaj.art-798f5cf7f3114fe5b011af50e016067c |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T15:18:57Z |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-798f5cf7f3114fe5b011af50e016067c2023-08-11T05:34:51ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-01-01111294305Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseasesQi Li0Anran Huo1Mengqi Li2Jiali Wang3Qiao Yin4Lumiao Chen5Xin Chu6Yuan Qin7Yuwan Qi8Yang Li9Hengxiang Cui10Qifei Cong11Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, ChinaDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, ChinaDepartment of Emergency Center, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, ChinaDepartment of Neurology, Huzhou Central Hospital, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang 313000, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Corresponding author. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; Corresponding author. Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, Jiangsu 215123, China.Adhesion G protein-coupled receptors (aGPCRs) are the second largest diverse group within the GPCR superfamily, which play critical roles in many physiological and pathological processes through cell–cell and cell–extracellular matrix interactions. The adhesion GPCR Adgrg6, also known as GPR126, is one of the better-characterized aGPCRs. GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals. Current studies have extended our understanding of GPR126-mediated roles during development and in human diseases. In this review, we highlighted these recent advances in GPR126 in expression profile, molecular structure, ligand–receptor interactions, and associated physiological and pathological functions in development and diseases.http://www.sciencedirect.com/science/article/pii/S2352304223000685Adhesion G protein-coupled receptorFunctionGPR126/Adgrg6LigandStructure |
| spellingShingle | Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases Genes and Diseases Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure |
| title | Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases |
| title_full | Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases |
| title_fullStr | Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases |
| title_full_unstemmed | Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases |
| title_short | Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases |
| title_sort | structure ligands and roles of gpr126 adgrg6 in the development and diseases |
| topic | Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223000685 |
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