Primary hyperhidrosis: From a genetics point of view
Primary hyperhidrosis is a disorder of profuse sweating which negatively influences a patient's quality of life and is caused because of over-activation of the sympathetic nervous system. It was believed that hyperhidrosis is a condition limited to only anxious individuals; however, this hypoth...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-12-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1568_22 |
| _version_ | 1826982446063681536 |
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| author | Asia Parveen Sidra Abbas Nasir Mehmood Mahtab Ahmed Mukhtar Patafi Usman Wajid Muhammad Luqman Shafia Arshad |
| author_facet | Asia Parveen Sidra Abbas Nasir Mehmood Mahtab Ahmed Mukhtar Patafi Usman Wajid Muhammad Luqman Shafia Arshad |
| author_sort | Asia Parveen |
| collection | DOAJ |
| description | Primary hyperhidrosis is a disorder of profuse sweating which negatively influences a patient's quality of life and is caused because of over-activation of the sympathetic nervous system. It was believed that hyperhidrosis is a condition limited to only anxious individuals; however, this hypothesis is discredited now. It has been found that people with a positive family history of primary hyperhidrosis are likely to suffer from this condition, suggesting a strong genetic basis. Genetic analysis has revealed a dominant autosomal pattern of inheritance with a variable degree of penetrance and is a sex-independent trait. It is a heterogeneous condition both genetically and clinically as different studies revealed variable genetics and clinical factors. There are no proper criteria for diagnosis as it is not treated as disease by most affected persons. Various studies revealed opposing results in localizing disease gene loci, so further genetic research is needed to pinpoint genes responsible for causing this debilitating condition. Gene expression profiling of human anxiety-causing genes in hyperhidrotic sufferers will also help to devise new treatment modalities. This review highlights the current genetic studies on hyperhidrosis, which may prove to be helpful in understanding the molecular mechanism governing hyperhidrosis. |
| first_indexed | 2024-04-24T16:04:03Z |
| format | Article |
| id | doaj.art-798fa7c0b0d0429e9544b97ecef074cc |
| institution | Directory Open Access Journal |
| issn | 2249-4863 2278-7135 |
| language | English |
| last_indexed | 2025-02-18T06:20:34Z |
| publishDate | 2023-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-798fa7c0b0d0429e9544b97ecef074cc2024-11-11T13:53:29ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352023-12-0112123028303210.4103/jfmpc.jfmpc_1568_22Primary hyperhidrosis: From a genetics point of viewAsia ParveenSidra AbbasNasir MehmoodMahtab Ahmed Mukhtar PatafiUsman WajidMuhammad LuqmanShafia ArshadPrimary hyperhidrosis is a disorder of profuse sweating which negatively influences a patient's quality of life and is caused because of over-activation of the sympathetic nervous system. It was believed that hyperhidrosis is a condition limited to only anxious individuals; however, this hypothesis is discredited now. It has been found that people with a positive family history of primary hyperhidrosis are likely to suffer from this condition, suggesting a strong genetic basis. Genetic analysis has revealed a dominant autosomal pattern of inheritance with a variable degree of penetrance and is a sex-independent trait. It is a heterogeneous condition both genetically and clinically as different studies revealed variable genetics and clinical factors. There are no proper criteria for diagnosis as it is not treated as disease by most affected persons. Various studies revealed opposing results in localizing disease gene loci, so further genetic research is needed to pinpoint genes responsible for causing this debilitating condition. Gene expression profiling of human anxiety-causing genes in hyperhidrotic sufferers will also help to devise new treatment modalities. This review highlights the current genetic studies on hyperhidrosis, which may prove to be helpful in understanding the molecular mechanism governing hyperhidrosis.https://journals.lww.com/10.4103/jfmpc.jfmpc_1568_22hyperhidrosis (hh)hyperhidroticprimary hyperhidrosis (ph)primary palmer hyperhidrosis (pph) |
| spellingShingle | Asia Parveen Sidra Abbas Nasir Mehmood Mahtab Ahmed Mukhtar Patafi Usman Wajid Muhammad Luqman Shafia Arshad Primary hyperhidrosis: From a genetics point of view Journal of Family Medicine and Primary Care hyperhidrosis (hh) hyperhidrotic primary hyperhidrosis (ph) primary palmer hyperhidrosis (pph) |
| title | Primary hyperhidrosis: From a genetics point of view |
| title_full | Primary hyperhidrosis: From a genetics point of view |
| title_fullStr | Primary hyperhidrosis: From a genetics point of view |
| title_full_unstemmed | Primary hyperhidrosis: From a genetics point of view |
| title_short | Primary hyperhidrosis: From a genetics point of view |
| title_sort | primary hyperhidrosis from a genetics point of view |
| topic | hyperhidrosis (hh) hyperhidrotic primary hyperhidrosis (ph) primary palmer hyperhidrosis (pph) |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_1568_22 |
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