Selection of adjuvants for vaccines targeting specific pathogens
Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be e...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-05-01
|
| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2019.1604231 |
| _version_ | 1797680366573584384 |
|---|---|
| author | Indranil Sarkar Ravendra Garg Sylvia van Drunen Littel-van den Hurk |
| author_facet | Indranil Sarkar Ravendra Garg Sylvia van Drunen Littel-van den Hurk |
| author_sort | Indranil Sarkar |
| collection | DOAJ |
| description | Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be elicited. Areas covered: Herein, we describe the recent progress in our understanding of the mode of action of adjuvants that are licensed for use in human vaccines or in clinical or pre-clinical stages at both innate and adaptive levels. Different pathogens have distinct characteristics, which require the host to mount an appropriate immune response against them. Adjuvants can be selected to elicit a tailor-made immune response to specific pathogens based on their unique properties. Identification of biomarkers of adjuvanticity for several candidate vaccines using omics-based technologies can unravel the mechanism of action of modern and experimental adjuvants. Expert opinion: Adjuvant technology has been revolutionized over the last two decades. In-depth understanding of the role of adjuvants in activating the innate immune system, combined with systems vaccinology approaches, have led to the development of next-generation, novel adjuvants that can be used in vaccines against challenging pathogens and in specific target populations. |
| first_indexed | 2024-03-11T23:28:58Z |
| format | Article |
| id | doaj.art-7990419fe442499eb1c98bd3b5dfa8d8 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:28:58Z |
| publishDate | 2019-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-7990419fe442499eb1c98bd3b5dfa8d82023-09-20T10:18:04ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952019-05-0118550552110.1080/14760584.2019.16042311604231Selection of adjuvants for vaccines targeting specific pathogensIndranil Sarkar0Ravendra Garg1Sylvia van Drunen Littel-van den Hurk2University of SaskatchewanUniversity of SaskatchewanUniversity of SaskatchewanIntroduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be elicited. Areas covered: Herein, we describe the recent progress in our understanding of the mode of action of adjuvants that are licensed for use in human vaccines or in clinical or pre-clinical stages at both innate and adaptive levels. Different pathogens have distinct characteristics, which require the host to mount an appropriate immune response against them. Adjuvants can be selected to elicit a tailor-made immune response to specific pathogens based on their unique properties. Identification of biomarkers of adjuvanticity for several candidate vaccines using omics-based technologies can unravel the mechanism of action of modern and experimental adjuvants. Expert opinion: Adjuvant technology has been revolutionized over the last two decades. In-depth understanding of the role of adjuvants in activating the innate immune system, combined with systems vaccinology approaches, have led to the development of next-generation, novel adjuvants that can be used in vaccines against challenging pathogens and in specific target populations.http://dx.doi.org/10.1080/14760584.2019.1604231adjuvantsmechanism of actionpathogensystems vaccinologyimmunity |
| spellingShingle | Indranil Sarkar Ravendra Garg Sylvia van Drunen Littel-van den Hurk Selection of adjuvants for vaccines targeting specific pathogens Expert Review of Vaccines adjuvants mechanism of action pathogen systems vaccinology immunity |
| title | Selection of adjuvants for vaccines targeting specific pathogens |
| title_full | Selection of adjuvants for vaccines targeting specific pathogens |
| title_fullStr | Selection of adjuvants for vaccines targeting specific pathogens |
| title_full_unstemmed | Selection of adjuvants for vaccines targeting specific pathogens |
| title_short | Selection of adjuvants for vaccines targeting specific pathogens |
| title_sort | selection of adjuvants for vaccines targeting specific pathogens |
| topic | adjuvants mechanism of action pathogen systems vaccinology immunity |
| url | http://dx.doi.org/10.1080/14760584.2019.1604231 |
| work_keys_str_mv | AT indranilsarkar selectionofadjuvantsforvaccinestargetingspecificpathogens AT ravendragarg selectionofadjuvantsforvaccinestargetingspecificpathogens AT sylviavandrunenlittelvandenhurk selectionofadjuvantsforvaccinestargetingspecificpathogens |