Comprehensive single-cell transcriptomic profiling reveals molecular subtypes and prognostic biomarkers with implications for targeted therapy in esophageal squamous cell carcinoma

Comprehensive single-cell transcriptomic profiling reveals molecular subtypes and prognostic biomarkers with implications for targeted therapy in esophageal squamous cell carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is a genetically heterogeneous disease with poor clinical outcomes. Identification of biomarkers linked to DNA replication stress may enable improved prognostic risk stratification and guide therapeutic decision making. We performed integrated si...

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Bibliographic Details
Main Authors: Dengfeng Zhang, Fangchao Zhao, Jing Li, Pengfei Guo, Haitao Liu, Tianxing Lu, Shujun Li, Zhirong Li, Yishuai Li
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Translational Oncology
Subjects:
Esophageal squamous cell carcinoma
Molecular subtypes
DNA replication stress response genes
PRKCB
Mendelian randomization
Immune infiltration
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324000755

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http://www.sciencedirect.com/science/article/pii/S1936523324000755

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