Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction

Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction

In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated. The binary systems studied were naproxen-indomethacin, naproxen-ibuprofen, naproxen-probucol, and indomethac...

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Bibliographic Details
Main Authors: Alžběta Zemánková, Fatima Hassouna, Martin Klajmon, Michal Fulem
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
co-amorphous systems
active pharmaceutical ingredients
phase diagrams
solid–liquid equilibrium
PC-SAFT
COSMO-RS
Online Access:https://www.mdpi.com/1420-3049/28/6/2492

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