Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents
Abstract Background Coronary artery aneurysms after drug eluting stents are rare. We present a case series of type II coronary aneurysms after implantation of Everolimus eluting stents including patients developing giant aneurysms with a toxic course. Case presentation Over a span of 3.5 years at ou...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02503-1 |
| _version_ | 1818280313092046848 |
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| author | Raghav Sharma Aditya Vikram Ruia Tek Singh Mahant |
| author_facet | Raghav Sharma Aditya Vikram Ruia Tek Singh Mahant |
| author_sort | Raghav Sharma |
| collection | DOAJ |
| description | Abstract Background Coronary artery aneurysms after drug eluting stents are rare. We present a case series of type II coronary aneurysms after implantation of Everolimus eluting stents including patients developing giant aneurysms with a toxic course. Case presentation Over a span of 3.5 years at our center 2572 patients were implanted Everolimus eluting stents out of which 4 patients developed coronary type II aneurysms an incidence of 0.00156 whereas 5838 patients were implanted Sirolimus eluting 2nd generation stents out of which 2 patients developed similar aneurysms with an incidence of 0.00034. The slight increase in incidence in Everolimus stents does not reach statistical significance (p = 0.054) and is limited by single centre non randomized study. We also propose a hypothesis that the slight increase in the incidence maybe due to allergy to Methacrylate present in Everolimus eluting Xience stent’s primer which is absent in other Sirolimus eluting stents used at our center but that needs to be further investigated. We also found some patients who developed giant aneurysms including Left main aneurysms. In our series operative repair of these patients had better outcomes than covered stent deployment but larger trials maybe needed to confirm the same. Conclusions Coronary artery aneurysms after stent implantation are rare but occasionally giant aneurysms are formed with a toxic course. The incidence and morphology of aneurysms after Everolimus and Sirolimus eluting stent deployment do not differ much. |
| first_indexed | 2024-12-12T23:47:14Z |
| format | Article |
| id | doaj.art-7994d175cfeb4ff8a9a3d3a5630130dc |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-12T23:47:14Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-7994d175cfeb4ff8a9a3d3a5630130dc2022-12-22T00:06:49ZengBMCBMC Cardiovascular Disorders1471-22612022-02-0122111110.1186/s12872-022-02503-1Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stentsRaghav Sharma0Aditya Vikram Ruia1Tek Singh Mahant2Interventional Cardiologist, HOD Cardiology Unit, Meditrina Hospital (Civil Hospital)Interventional Cardiologist, HOD Cardiology Unit, Meditrina Hospital (Civil Hospital)Senior Cardiothoracic Surgeon, Executive Director Cardiac Surgery, Fortis Healthcare HospitalAbstract Background Coronary artery aneurysms after drug eluting stents are rare. We present a case series of type II coronary aneurysms after implantation of Everolimus eluting stents including patients developing giant aneurysms with a toxic course. Case presentation Over a span of 3.5 years at our center 2572 patients were implanted Everolimus eluting stents out of which 4 patients developed coronary type II aneurysms an incidence of 0.00156 whereas 5838 patients were implanted Sirolimus eluting 2nd generation stents out of which 2 patients developed similar aneurysms with an incidence of 0.00034. The slight increase in incidence in Everolimus stents does not reach statistical significance (p = 0.054) and is limited by single centre non randomized study. We also propose a hypothesis that the slight increase in the incidence maybe due to allergy to Methacrylate present in Everolimus eluting Xience stent’s primer which is absent in other Sirolimus eluting stents used at our center but that needs to be further investigated. We also found some patients who developed giant aneurysms including Left main aneurysms. In our series operative repair of these patients had better outcomes than covered stent deployment but larger trials maybe needed to confirm the same. Conclusions Coronary artery aneurysms after stent implantation are rare but occasionally giant aneurysms are formed with a toxic course. The incidence and morphology of aneurysms after Everolimus and Sirolimus eluting stent deployment do not differ much.https://doi.org/10.1186/s12872-022-02503-1Coronary artery aneurysmXience stentMethacrylateGiant aneurysmLeft main aneurysmCase report |
| spellingShingle | Raghav Sharma Aditya Vikram Ruia Tek Singh Mahant Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents BMC Cardiovascular Disorders Coronary artery aneurysm Xience stent Methacrylate Giant aneurysm Left main aneurysm Case report |
| title | Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents |
| title_full | Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents |
| title_fullStr | Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents |
| title_full_unstemmed | Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents |
| title_short | Case series of coronary artery aneurysms after Everolimus eluting stent implantation and comparison with Sirolimus eluting stents |
| title_sort | case series of coronary artery aneurysms after everolimus eluting stent implantation and comparison with sirolimus eluting stents |
| topic | Coronary artery aneurysm Xience stent Methacrylate Giant aneurysm Left main aneurysm Case report |
| url | https://doi.org/10.1186/s12872-022-02503-1 |
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