Microbial Interactions during Upper Respiratory Tract Infections
Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus often colonize the nasopharynx. Children are susceptible to bacterial infections during or soon after upper respiratory tract infection (URI). We describe colonization with these 4 bacteria species alo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2008-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/14/10/08-0119_article |
| _version_ | 1818309028914135040 |
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| author | Melinda M. Pettigrew Janneane F. Gent Krystal Revai Janak A. Patel Tasnee Chonmaitree |
| author_facet | Melinda M. Pettigrew Janneane F. Gent Krystal Revai Janak A. Patel Tasnee Chonmaitree |
| author_sort | Melinda M. Pettigrew |
| collection | DOAJ |
| description | Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus often colonize the nasopharynx. Children are susceptible to bacterial infections during or soon after upper respiratory tract infection (URI). We describe colonization with these 4 bacteria species alone or in combination during URI. Data were from a prospective cohort of healthy children 6 to 36 months of age followed up for 1 year. Analyses of 968 swabs from 212 children indicated that S. pneumoniae colonization is negatively associated with colonization by H. influenzae. Competitive interactions shifted when H. influenzae and M. catarrhalis colonized together. In this situation, the likelihood of colonization with all 3 species is higher. Negative associations were identified between S. pneumoniae and S. aureus and between H. influenzae and S. aureus. Polymicrobial interactions differed by number and species of bacteria present. Antimicrobial therapy and vaccination strategies targeting specific bacterial species may alter the flora in unforeseen ways. |
| first_indexed | 2024-12-13T07:23:40Z |
| format | Article |
| id | doaj.art-79954ab933d54d87a09eec39246ac1c9 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-13T07:23:40Z |
| publishDate | 2008-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-79954ab933d54d87a09eec39246ac1c92022-12-21T23:55:21ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-10-0114101584159110.3201/eid1410.080119Microbial Interactions during Upper Respiratory Tract InfectionsMelinda M. PettigrewJanneane F. GentKrystal RevaiJanak A. PatelTasnee ChonmaitreeStreptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus often colonize the nasopharynx. Children are susceptible to bacterial infections during or soon after upper respiratory tract infection (URI). We describe colonization with these 4 bacteria species alone or in combination during URI. Data were from a prospective cohort of healthy children 6 to 36 months of age followed up for 1 year. Analyses of 968 swabs from 212 children indicated that S. pneumoniae colonization is negatively associated with colonization by H. influenzae. Competitive interactions shifted when H. influenzae and M. catarrhalis colonized together. In this situation, the likelihood of colonization with all 3 species is higher. Negative associations were identified between S. pneumoniae and S. aureus and between H. influenzae and S. aureus. Polymicrobial interactions differed by number and species of bacteria present. Antimicrobial therapy and vaccination strategies targeting specific bacterial species may alter the flora in unforeseen ways.https://wwwnc.cdc.gov/eid/article/14/10/08-0119_articleStreptococcus pneumoniaeHaemophilus influenzaeMoraxella catarrhalisStaphylococcus aureuscolonizationcompetition |
| spellingShingle | Melinda M. Pettigrew Janneane F. Gent Krystal Revai Janak A. Patel Tasnee Chonmaitree Microbial Interactions during Upper Respiratory Tract Infections Emerging Infectious Diseases Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis Staphylococcus aureus colonization competition |
| title | Microbial Interactions during Upper Respiratory Tract Infections |
| title_full | Microbial Interactions during Upper Respiratory Tract Infections |
| title_fullStr | Microbial Interactions during Upper Respiratory Tract Infections |
| title_full_unstemmed | Microbial Interactions during Upper Respiratory Tract Infections |
| title_short | Microbial Interactions during Upper Respiratory Tract Infections |
| title_sort | microbial interactions during upper respiratory tract infections |
| topic | Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis Staphylococcus aureus colonization competition |
| url | https://wwwnc.cdc.gov/eid/article/14/10/08-0119_article |
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