Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

Over-accumulation of oxalate in humans may lead to nephrolithiasis and nephrocalcinosis. Humans lack endogenous oxalate degradation pathways (ODP), but intestinal microbes can degrade oxalate using multiple ODPs and protect against its absorption. The exact oxalate-degrading taxa in the human microb...

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Bibliographic Details
Main Authors: Menghan Liu, Joseph C Devlin, Jiyuan Hu, Angelina Volkova, Thomas W Battaglia, Melody Ho, John R Asplin, Allyson Byrd, P'ng Loke, Huilin Li, Kelly V Ruggles, Aristotelis Tsirigos, Martin J Blaser, Lama Nazzal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
microbiota
oxalate metabolism
metatranscriptome
metagenome
IBD
gene expressions
Online Access:https://elifesciences.org/articles/63642

Internet

https://elifesciences.org/articles/63642

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