Transcriptional profiles of Treponema denticola in response to environmental conditions.
The periodontal pathogen T. denticola resides in a stressful environment rife with challenges, the human oral cavity. Knowledge of the stress response capabilities of this invasive spirochete is currently very limited. Whole genome expression profiles in response to different suspected stresses incl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-10-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2965109?pdf=render |
| _version_ | 1811269207345594368 |
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| author | Ian McHardy Caroline Keegan Jee-Hyun Sim Wenyuan Shi Renate Lux |
| author_facet | Ian McHardy Caroline Keegan Jee-Hyun Sim Wenyuan Shi Renate Lux |
| author_sort | Ian McHardy |
| collection | DOAJ |
| description | The periodontal pathogen T. denticola resides in a stressful environment rife with challenges, the human oral cavity. Knowledge of the stress response capabilities of this invasive spirochete is currently very limited. Whole genome expression profiles in response to different suspected stresses including heat shock, osmotic downshift, oxygen and blood exposure were examined. Most of the genes predicted to encode conserved heat shock proteins (HSPs) were found to be induced under heat and oxygen stress. Several of these HSPs also seem to be important for survival in hypotonic solutions and blood. In addition to HSPs, differential regulation of many genes encoding metabolic proteins, hypothetical proteins, transcriptional regulators and transporters was observed in patterns that could betoken functional associations. In summary, stress responses in T. denticola exhibit many similarities to the corresponding stress responses in other organisms but also employ unique components including the induction of hypothetical proteins. |
| first_indexed | 2024-04-12T21:36:45Z |
| format | Article |
| id | doaj.art-799b6e33a8684b1388ac726fa3b41c8f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T21:36:45Z |
| publishDate | 2010-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-799b6e33a8684b1388ac726fa3b41c8f2022-12-22T03:15:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-10-01510e1365510.1371/journal.pone.0013655Transcriptional profiles of Treponema denticola in response to environmental conditions.Ian McHardyCaroline KeeganJee-Hyun SimWenyuan ShiRenate LuxThe periodontal pathogen T. denticola resides in a stressful environment rife with challenges, the human oral cavity. Knowledge of the stress response capabilities of this invasive spirochete is currently very limited. Whole genome expression profiles in response to different suspected stresses including heat shock, osmotic downshift, oxygen and blood exposure were examined. Most of the genes predicted to encode conserved heat shock proteins (HSPs) were found to be induced under heat and oxygen stress. Several of these HSPs also seem to be important for survival in hypotonic solutions and blood. In addition to HSPs, differential regulation of many genes encoding metabolic proteins, hypothetical proteins, transcriptional regulators and transporters was observed in patterns that could betoken functional associations. In summary, stress responses in T. denticola exhibit many similarities to the corresponding stress responses in other organisms but also employ unique components including the induction of hypothetical proteins.http://europepmc.org/articles/PMC2965109?pdf=render |
| spellingShingle | Ian McHardy Caroline Keegan Jee-Hyun Sim Wenyuan Shi Renate Lux Transcriptional profiles of Treponema denticola in response to environmental conditions. PLoS ONE |
| title | Transcriptional profiles of Treponema denticola in response to environmental conditions. |
| title_full | Transcriptional profiles of Treponema denticola in response to environmental conditions. |
| title_fullStr | Transcriptional profiles of Treponema denticola in response to environmental conditions. |
| title_full_unstemmed | Transcriptional profiles of Treponema denticola in response to environmental conditions. |
| title_short | Transcriptional profiles of Treponema denticola in response to environmental conditions. |
| title_sort | transcriptional profiles of treponema denticola in response to environmental conditions |
| url | http://europepmc.org/articles/PMC2965109?pdf=render |
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