Cell-free DNA screening in twin pregnancies
Cell-free DNA (cfDNA) screening for fetal aneuploidies is clinically available and exhibits better performance than conventional serum screening tests. However, data on the clinical performance of cfDNA screening in twin pregnancies are limited. In this review, we summarized the clinical performance...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2024-03-01
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| Series: | Obstetrics & Gynecology Science |
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| Online Access: | http://ogscience.org/upload/pdf/ogs-23135.pdf |
| _version_ | 1797261915673591808 |
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| author | Hye Yeon Boo You Jung Han |
| author_facet | Hye Yeon Boo You Jung Han |
| author_sort | Hye Yeon Boo |
| collection | DOAJ |
| description | Cell-free DNA (cfDNA) screening for fetal aneuploidies is clinically available and exhibits better performance than conventional serum screening tests. However, data on the clinical performance of cfDNA screening in twin pregnancies are limited. In this review, we summarized the clinical performance and evaluated the feasibility of cfDNA screening in twin pregnancies based on recent studies and recommendations. The performance of cfDNA screening for trisomy 21 in twin pregnancies is similar to that in singleton pregnancies. Specifically, cfDNA screening has a higher detection rate and lower false-positive rate compared with conventional serum screening. Consequently, recent international guidelines from several academic communities have recommended that cfDNA screening for aneuploidy in twin pregnancies could be considered. Moreover, twin pregnancies can present with specific conditions, such as different zygosities and vanishing twins; therefore, individualized counseling and management are required. Further clinical studies with more twin pregnancies are required for a more accurate analysis. |
| first_indexed | 2024-04-24T23:48:48Z |
| format | Article |
| id | doaj.art-799e6eb9e7bb41a98029fba8de6e9ae7 |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-04-24T23:48:48Z |
| publishDate | 2024-03-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-799e6eb9e7bb41a98029fba8de6e9ae72024-03-15T02:07:37ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802024-03-0167216016810.5468/ogs.231358806Cell-free DNA screening in twin pregnanciesHye Yeon Boo0You Jung Han1 Department of Obstetrics and Gynecology, CHA Ilsan Medical Center, Goyang, Korea Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, Seoul, KoreaCell-free DNA (cfDNA) screening for fetal aneuploidies is clinically available and exhibits better performance than conventional serum screening tests. However, data on the clinical performance of cfDNA screening in twin pregnancies are limited. In this review, we summarized the clinical performance and evaluated the feasibility of cfDNA screening in twin pregnancies based on recent studies and recommendations. The performance of cfDNA screening for trisomy 21 in twin pregnancies is similar to that in singleton pregnancies. Specifically, cfDNA screening has a higher detection rate and lower false-positive rate compared with conventional serum screening. Consequently, recent international guidelines from several academic communities have recommended that cfDNA screening for aneuploidy in twin pregnancies could be considered. Moreover, twin pregnancies can present with specific conditions, such as different zygosities and vanishing twins; therefore, individualized counseling and management are required. Further clinical studies with more twin pregnancies are required for a more accurate analysis.http://ogscience.org/upload/pdf/ogs-23135.pdfprenatal cfdna screeningtwin pregnanciesprenatal screeningprenatal diagnosis |
| spellingShingle | Hye Yeon Boo You Jung Han Cell-free DNA screening in twin pregnancies Obstetrics & Gynecology Science prenatal cfdna screening twin pregnancies prenatal screening prenatal diagnosis |
| title | Cell-free DNA screening in twin pregnancies |
| title_full | Cell-free DNA screening in twin pregnancies |
| title_fullStr | Cell-free DNA screening in twin pregnancies |
| title_full_unstemmed | Cell-free DNA screening in twin pregnancies |
| title_short | Cell-free DNA screening in twin pregnancies |
| title_sort | cell free dna screening in twin pregnancies |
| topic | prenatal cfdna screening twin pregnancies prenatal screening prenatal diagnosis |
| url | http://ogscience.org/upload/pdf/ogs-23135.pdf |
| work_keys_str_mv | AT hyeyeonboo cellfreednascreeningintwinpregnancies AT youjunghan cellfreednascreeningintwinpregnancies |