Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS)
Abstract Gestational diabetes mellitus (GDM) is one of the most common pregnancy‐related complications; it is associated with adverse pregnancy outcomes and metabolic disorders in offspring, consistent with the concept of the developmental origins of health and disease. This cohort study of women wi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13796 |
| _version_ | 1818491974013943808 |
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| author | Tetsuo Sekine Kyoichiro Tsuchiya Hiroyuki Uchinuma Sayaka Horiuchi Megumi Kushima Sanae Otawa Hiroshi Yokomichi Kunio Miyake Yuka Akiyama Tadao Ooka Reiji Kojima Ryoji Shinohara Zentaro Yamagata The Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group |
| author_facet | Tetsuo Sekine Kyoichiro Tsuchiya Hiroyuki Uchinuma Sayaka Horiuchi Megumi Kushima Sanae Otawa Hiroshi Yokomichi Kunio Miyake Yuka Akiyama Tadao Ooka Reiji Kojima Ryoji Shinohara Zentaro Yamagata The Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group |
| author_sort | Tetsuo Sekine |
| collection | DOAJ |
| description | Abstract Gestational diabetes mellitus (GDM) is one of the most common pregnancy‐related complications; it is associated with adverse pregnancy outcomes and metabolic disorders in offspring, consistent with the concept of the developmental origins of health and disease. This cohort study of women without diabetes (n = 761), who were part of the Yamanashi Adjunct Study of the Japan Environment and Children’s Study, aimed to explore the associations between maternal GDM and their offspring’s level of high‐sensitivity C‐reactive protein (hsCRP), a biomarker of inflammatory and cardiovascular diseases. We analyzed the associations between GDM and the offspring’s hsCRP levels using a multiple logistic regression model. A mother with GDM significantly increased the risk for high hsCRP level by 4.07‐fold (≥2.0 mg/L) in the child. As such, maternal GDM was significantly associated with increased serum hsCRP levels in 8‐year‐old children. |
| first_indexed | 2024-12-10T17:37:34Z |
| format | Article |
| id | doaj.art-799eae6d39db4731b32b41dad83e5d0f |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-10T17:37:34Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-799eae6d39db4731b32b41dad83e5d0f2022-12-22T01:39:29ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-08-011381444144710.1111/jdi.13796Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS)Tetsuo Sekine0Kyoichiro Tsuchiya1Hiroyuki Uchinuma2Sayaka Horiuchi3Megumi Kushima4Sanae Otawa5Hiroshi Yokomichi6Kunio Miyake7Yuka Akiyama8Tadao Ooka9Reiji Kojima10Ryoji Shinohara11Zentaro Yamagata12The Yamanashi Adjunct Study of the Japan Environment, Children’s Study GroupInterdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Chuo City JapanInterdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Chuo City JapanInterdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Chuo City JapanCenter for Birth Cohort Studies University of Yamanashi Chuo City JapanCenter for Birth Cohort Studies University of Yamanashi Chuo City JapanCenter for Birth Cohort Studies University of Yamanashi Chuo City JapanDepartment of Health Sciences School of Medicine University of Yamanashi Chuo City JapanDepartment of Health Sciences School of Medicine University of Yamanashi Chuo City JapanDepartment of Health Sciences School of Medicine University of Yamanashi Chuo City JapanDepartment of Health Sciences School of Medicine University of Yamanashi Chuo City JapanDepartment of Health Sciences School of Medicine University of Yamanashi Chuo City JapanCenter for Birth Cohort Studies University of Yamanashi Chuo City JapanCenter for Birth Cohort Studies University of Yamanashi Chuo City JapanAbstract Gestational diabetes mellitus (GDM) is one of the most common pregnancy‐related complications; it is associated with adverse pregnancy outcomes and metabolic disorders in offspring, consistent with the concept of the developmental origins of health and disease. This cohort study of women without diabetes (n = 761), who were part of the Yamanashi Adjunct Study of the Japan Environment and Children’s Study, aimed to explore the associations between maternal GDM and their offspring’s level of high‐sensitivity C‐reactive protein (hsCRP), a biomarker of inflammatory and cardiovascular diseases. We analyzed the associations between GDM and the offspring’s hsCRP levels using a multiple logistic regression model. A mother with GDM significantly increased the risk for high hsCRP level by 4.07‐fold (≥2.0 mg/L) in the child. As such, maternal GDM was significantly associated with increased serum hsCRP levels in 8‐year‐old children.https://doi.org/10.1111/jdi.13796Cohort studyMetabolic syndromeObesity |
| spellingShingle | Tetsuo Sekine Kyoichiro Tsuchiya Hiroyuki Uchinuma Sayaka Horiuchi Megumi Kushima Sanae Otawa Hiroshi Yokomichi Kunio Miyake Yuka Akiyama Tadao Ooka Reiji Kojima Ryoji Shinohara Zentaro Yamagata The Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) Journal of Diabetes Investigation Cohort study Metabolic syndrome Obesity |
| title | Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) |
| title_full | Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) |
| title_fullStr | Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) |
| title_full_unstemmed | Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) |
| title_short | Association between maternal gestational diabetes mellitus and high‐sensitivity C‐reactive protein levels in 8‐year‐old children: The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS) |
| title_sort | association between maternal gestational diabetes mellitus and high sensitivity c reactive protein levels in 8 year old children the yamanashi adjunct study of the japan environment and children s study jecs |
| topic | Cohort study Metabolic syndrome Obesity |
| url | https://doi.org/10.1111/jdi.13796 |
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