Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting
Aleksandra Szylińska,1 Mariusz J Listewnik,2 Iwona Rotter,1 Aleksandra Rył,3 Andrzej Biskupski,2 Mirosław Brykczyński2 1Department of Medical Rehabilitation, 2Department of Cardiac Surgery, 3Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-07-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/analysis-of-the-influence-of-respiratory-disorders-observed-in-preoper-peer-reviewed-article-CIA |
| _version_ | 1819008830976032768 |
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| author | Szylińska A Listewnik MJ Rotter I Rył A Biskupski A Brykczyński M |
| author_facet | Szylińska A Listewnik MJ Rotter I Rył A Biskupski A Brykczyński M |
| author_sort | Szylińska A |
| collection | DOAJ |
| description | Aleksandra Szylińska,1 Mariusz J Listewnik,2 Iwona Rotter,1 Aleksandra Rył,3 Andrzej Biskupski,2 Mirosław Brykczyński2 1Department of Medical Rehabilitation, 2Department of Cardiac Surgery, 3Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland Background: Preoperative spirometry provides measurable information about the occurrence of respiratory disorders. The aim of this study was to assess the association between preoperative spirometry abnormalities and the intensification of early inflammatory responses in patients following coronary artery bypass graft in extracorporeal circulation. Material and methods: The study involved 810 patients (625 men and 185 women) aged 65.4±7.9 years who were awaiting isolated coronary artery bypass surgery. On the basis of spirometry performed on the day of admittance to the hospital, the patients were divided into three groups. Patients without respiratory problems constituted 78.8% of the entire group. Restricted breathing was revealed by spirometry in 14.9% and obstructive breathing in 6.3% of patients. Results: Inter-group analysis showed statistically significant differences in C-reactive protein (CRP) between patients with restrictive spirometry abnormalities and patients without any pulmonary dysfunction. CRP concentrations differed before surgery (P=0.006) and on the second (P<0.001), fourth (P=0.005) and sixth days after surgery (P=0.029). There was a negative correlation between CRP levels and FEV1. Conclusion: In our study, the most common pulmonary disorders in the coronary artery bypass graft patients were restrictive. Patients with abnormal spirometry results from restrictive respiratory disorders have an elevated level of generalized inflammatory response both before and after the isolated coronary artery bypass surgery. Therefore, this group of patients should be given special postoperative monitoring and, in particular, intensive respiratory rehabilitation immediately after reconstitution. Keywords: pulmonary function, C-reactive protein, cardiac surgery |
| first_indexed | 2024-12-21T00:46:43Z |
| format | Article |
| id | doaj.art-799f0868e47145bd9497695f20c551d3 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-21T00:46:43Z |
| publishDate | 2017-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-799f0868e47145bd9497695f20c551d32022-12-21T19:21:30ZengDove Medical PressClinical Interventions in Aging1178-19982017-07-01Volume 121123112933761Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass graftingSzylińska AListewnik MJRotter IRył ABiskupski ABrykczyński MAleksandra Szylińska,1 Mariusz J Listewnik,2 Iwona Rotter,1 Aleksandra Rył,3 Andrzej Biskupski,2 Mirosław Brykczyński2 1Department of Medical Rehabilitation, 2Department of Cardiac Surgery, 3Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland Background: Preoperative spirometry provides measurable information about the occurrence of respiratory disorders. The aim of this study was to assess the association between preoperative spirometry abnormalities and the intensification of early inflammatory responses in patients following coronary artery bypass graft in extracorporeal circulation. Material and methods: The study involved 810 patients (625 men and 185 women) aged 65.4±7.9 years who were awaiting isolated coronary artery bypass surgery. On the basis of spirometry performed on the day of admittance to the hospital, the patients were divided into three groups. Patients without respiratory problems constituted 78.8% of the entire group. Restricted breathing was revealed by spirometry in 14.9% and obstructive breathing in 6.3% of patients. Results: Inter-group analysis showed statistically significant differences in C-reactive protein (CRP) between patients with restrictive spirometry abnormalities and patients without any pulmonary dysfunction. CRP concentrations differed before surgery (P=0.006) and on the second (P<0.001), fourth (P=0.005) and sixth days after surgery (P=0.029). There was a negative correlation between CRP levels and FEV1. Conclusion: In our study, the most common pulmonary disorders in the coronary artery bypass graft patients were restrictive. Patients with abnormal spirometry results from restrictive respiratory disorders have an elevated level of generalized inflammatory response both before and after the isolated coronary artery bypass surgery. Therefore, this group of patients should be given special postoperative monitoring and, in particular, intensive respiratory rehabilitation immediately after reconstitution. Keywords: pulmonary function, C-reactive protein, cardiac surgeryhttps://www.dovepress.com/analysis-of-the-influence-of-respiratory-disorders-observed-in-preoper-peer-reviewed-article-CIAspirometryC-reactive proteincoronary artery bypass graft (CABG) |
| spellingShingle | Szylińska A Listewnik MJ Rotter I Rył A Biskupski A Brykczyński M Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting Clinical Interventions in Aging spirometry C-reactive protein coronary artery bypass graft (CABG) |
| title | Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting |
| title_full | Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting |
| title_fullStr | Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting |
| title_full_unstemmed | Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting |
| title_short | Analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting |
| title_sort | analysis of the influence of respiratory disorders observed in preoperative spirometry on the dynamics of early inflammatory response in patients undergoing isolated coronary artery bypass grafting |
| topic | spirometry C-reactive protein coronary artery bypass graft (CABG) |
| url | https://www.dovepress.com/analysis-of-the-influence-of-respiratory-disorders-observed-in-preoper-peer-reviewed-article-CIA |
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