Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

In this article we present the synthesis of enantiomerically pure sulfoxide and study the influence of this compound on hemostasis. Detailed NMR studies and molecular dynamics simulations using sodium dodecyl sulfate (SDS) membrane models indicated that the bicyclic fragment of sulfoxide was embedde...

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Bibliographic Details
Main Authors: Liliya E. Nikitina, Sergei V. Kiselev, Valeriya A. Startseva, Andrei V. Bodrov, Zulfiya R. Azizova, Olga T. Shipina, Inna V. Fedyunina, Sergei V. Boichuk, Olga A. Lodochnikova, Vladimir V. Klochkov, Leisan F. Galiullina, Aliya V. Khaliullina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
terpenes
sulfoxides
platelets aggregation
coagulation activity
molecular mechanism of coagulation activity
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00116/full

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