Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Abstract Background Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxi...

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Bibliographic Details
Main Authors: Hongzhi Hu, Wenbo Yang, Zihui Liang, Zezhu Zhou, Qingcheng Song, Weijian Liu, Xiangtian Deng, Jian Zhu, Xin Xing, Binglong Zhong, Baichuan Wang, Shangyu Wang, Zengwu Shao, Yingze Zhang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Nanobiotechnology
Subjects:
Oxidative stress
Mitochondrial dysfunction
Endoplasmic reticulum stress
Osteosarcoma
Lycorine
Gold nanostars
Online Access:https://doi.org/10.1186/s12951-021-00933-1

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