Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet
To examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats borne to dams with gestational HFD/obesity. T...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/10/3428 |
| _version_ | 1797568171578753024 |
|---|---|
| author | Mei-Hsin Hsu Jiunn-Ming Sheen I-Chun Lin Hong-Ren Yu Mao-Meng Tiao You-Lin Tain Li-Tung Huang |
| author_facet | Mei-Hsin Hsu Jiunn-Ming Sheen I-Chun Lin Hong-Ren Yu Mao-Meng Tiao You-Lin Tain Li-Tung Huang |
| author_sort | Mei-Hsin Hsu |
| collection | DOAJ |
| description | To examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats borne to dams with gestational HFD/obesity. Then, we assessed the possible priming effect of a subsequent insult, male offspring were weaned onto either a rat chow or a HFD. Spatial learning and memory were assessed by Morris water maze test. Blood pressure and peripheral insulin resistance were examined. Maternal HFD/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pAKT), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor (BDNF) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. Maternal resveratrol treatment restored adiponectin, pAKT, and BDNF in fetal brain. It also reduced body weight, peripheral insulin resistance, increased blood pressure, and alleviated cognitive impairment in adult male offspring with combined maternal HFD and postnatal HFD. Maternal resveratrol treatment restored hippocampal pAKT and BDNF in rats with combined maternal HFD and postnatal HFD in adult male offspring dorsal hippocampus. Maternal resveratrol intake protects the fetal brain in the context of maternal HFD/obesity. It effectively reduced the synergistic effects of maternal HFD/obesity and postnatal HFD on metabolic disturbances and cognitive impairment in adult male offspring. Our data suggest that maternal resveratrol intake may serve as an effective therapeutic strategy in the context of maternal HFD/obesity. |
| first_indexed | 2024-03-10T19:52:38Z |
| format | Article |
| id | doaj.art-79a22314a8784c0d8a2ba392eadd553e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:52:38Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-79a22314a8784c0d8a2ba392eadd553e2023-11-20T00:14:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110342810.3390/ijms21103428Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat DietMei-Hsin Hsu0Jiunn-Ming Sheen1I-Chun Lin2Hong-Ren Yu3Mao-Meng Tiao4You-Lin Tain5Li-Tung Huang6Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanTo examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats borne to dams with gestational HFD/obesity. Then, we assessed the possible priming effect of a subsequent insult, male offspring were weaned onto either a rat chow or a HFD. Spatial learning and memory were assessed by Morris water maze test. Blood pressure and peripheral insulin resistance were examined. Maternal HFD/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pAKT), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor (BDNF) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. Maternal resveratrol treatment restored adiponectin, pAKT, and BDNF in fetal brain. It also reduced body weight, peripheral insulin resistance, increased blood pressure, and alleviated cognitive impairment in adult male offspring with combined maternal HFD and postnatal HFD. Maternal resveratrol treatment restored hippocampal pAKT and BDNF in rats with combined maternal HFD and postnatal HFD in adult male offspring dorsal hippocampus. Maternal resveratrol intake protects the fetal brain in the context of maternal HFD/obesity. It effectively reduced the synergistic effects of maternal HFD/obesity and postnatal HFD on metabolic disturbances and cognitive impairment in adult male offspring. Our data suggest that maternal resveratrol intake may serve as an effective therapeutic strategy in the context of maternal HFD/obesity.https://www.mdpi.com/1422-0067/21/10/3428maternal high-fat dietmaternal obesitymaternal resveratrolpostnatal high-fat dietspatialhippocampus |
| spellingShingle | Mei-Hsin Hsu Jiunn-Ming Sheen I-Chun Lin Hong-Ren Yu Mao-Meng Tiao You-Lin Tain Li-Tung Huang Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet International Journal of Molecular Sciences maternal high-fat diet maternal obesity maternal resveratrol postnatal high-fat diet spatial hippocampus |
| title | Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet |
| title_full | Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet |
| title_fullStr | Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet |
| title_full_unstemmed | Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet |
| title_short | Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet |
| title_sort | effects of maternal resveratrol on maternal high fat diet obesity with or without postnatal high fat diet |
| topic | maternal high-fat diet maternal obesity maternal resveratrol postnatal high-fat diet spatial hippocampus |
| url | https://www.mdpi.com/1422-0067/21/10/3428 |
| work_keys_str_mv | AT meihsinhsu effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet AT jiunnmingsheen effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet AT ichunlin effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet AT hongrenyu effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet AT maomengtiao effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet AT youlintain effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet AT litunghuang effectsofmaternalresveratrolonmaternalhighfatdietobesitywithorwithoutpostnatalhighfatdiet |