Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes
Modern cellular biology faces several major obstacles, such as the determination of the concentration of active sites corresponding to chemical substances. In recent years, the popular small-molecule fluorescent probes have completely changed the understanding of cellular biology through their high...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.915609/full |
| _version_ | 1818195561886515200 |
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| author | Huimin Chen Huimin Chen Zhenjie Yu Shiwei Ren Yuyu Qiu |
| author_facet | Huimin Chen Huimin Chen Zhenjie Yu Shiwei Ren Yuyu Qiu |
| author_sort | Huimin Chen |
| collection | DOAJ |
| description | Modern cellular biology faces several major obstacles, such as the determination of the concentration of active sites corresponding to chemical substances. In recent years, the popular small-molecule fluorescent probes have completely changed the understanding of cellular biology through their high sensitivity toward specific substances in various organisms. Mitochondria and lysosomes are significant organelles in various organisms, and their interaction is closely related to the development of various diseases. The investigation of their structure and function has gathered tremendous attention from biologists. The advanced nanoscopic technologies have replaced the diffraction-limited conventional imaging techniques and have been developed to explore the unknown aspects of mitochondria and lysosomes with a sub-diffraction resolution. Recent progress in this field has yielded several excellent mitochondria- and lysosome-targeted fluorescent probes, some of which have demonstrated significant biological applications. Herein, we review studies that have been carried out to date and suggest future research directions that will harness the considerable potential of mitochondria- and lysosome-targeted fluorescent probes. |
| first_indexed | 2024-12-12T01:20:09Z |
| format | Article |
| id | doaj.art-79a24c4f609c4efdbd3fcb59dbec0abf |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T01:20:09Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-79a24c4f609c4efdbd3fcb59dbec0abf2022-12-22T00:43:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.915609915609Fluorescent Probes Design Strategies for Imaging Mitochondria and LysosomesHuimin Chen0Huimin Chen1Zhenjie Yu2Shiwei Ren3Yuyu Qiu4Institute of Materia Medica, Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Biochemistry, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, ChinaInstitute of Materia Medica, Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaInstitute of Materia Medica, Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Biochemistry, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an, ChinaModern cellular biology faces several major obstacles, such as the determination of the concentration of active sites corresponding to chemical substances. In recent years, the popular small-molecule fluorescent probes have completely changed the understanding of cellular biology through their high sensitivity toward specific substances in various organisms. Mitochondria and lysosomes are significant organelles in various organisms, and their interaction is closely related to the development of various diseases. The investigation of their structure and function has gathered tremendous attention from biologists. The advanced nanoscopic technologies have replaced the diffraction-limited conventional imaging techniques and have been developed to explore the unknown aspects of mitochondria and lysosomes with a sub-diffraction resolution. Recent progress in this field has yielded several excellent mitochondria- and lysosome-targeted fluorescent probes, some of which have demonstrated significant biological applications. Herein, we review studies that have been carried out to date and suggest future research directions that will harness the considerable potential of mitochondria- and lysosome-targeted fluorescent probes.https://www.frontiersin.org/articles/10.3389/fphar.2022.915609/fulllysosomesmitochondriasmall-molecule fluorescent probeinteractionimaging |
| spellingShingle | Huimin Chen Huimin Chen Zhenjie Yu Shiwei Ren Yuyu Qiu Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes Frontiers in Pharmacology lysosomes mitochondria small-molecule fluorescent probe interaction imaging |
| title | Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes |
| title_full | Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes |
| title_fullStr | Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes |
| title_full_unstemmed | Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes |
| title_short | Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes |
| title_sort | fluorescent probes design strategies for imaging mitochondria and lysosomes |
| topic | lysosomes mitochondria small-molecule fluorescent probe interaction imaging |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.915609/full |
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