Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy
During pregnancy, cycles of hypoxia and oxidative stress play a key role in the proper development of the fetus. Hypoxia during the first weeks is crucial for placental development, while the increase in oxygen due to the influx of maternal blood stimulates endothelial growth and angiogenesis. Howev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/648 |
| _version_ | 1797437093311414272 |
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| author | Giorgia Sebastiani Elisabet Navarro-Tapia Laura Almeida-Toledano Mariona Serra-Delgado Anna Lucia Paltrinieri Óscar García-Algar Vicente Andreu-Fernández |
| author_facet | Giorgia Sebastiani Elisabet Navarro-Tapia Laura Almeida-Toledano Mariona Serra-Delgado Anna Lucia Paltrinieri Óscar García-Algar Vicente Andreu-Fernández |
| author_sort | Giorgia Sebastiani |
| collection | DOAJ |
| description | During pregnancy, cycles of hypoxia and oxidative stress play a key role in the proper development of the fetus. Hypoxia during the first weeks is crucial for placental development, while the increase in oxygen due to the influx of maternal blood stimulates endothelial growth and angiogenesis. However, an imbalance in the number of oxidative molecules due to endogenous or exogenous factors can overwhelm defense systems and lead to excessive production of reactive oxygen species (ROS). Many pregnancy complications, generated by systemic inflammation and placental vasoconstriction, such as preeclampsia (PE), fetal growth restriction (FGR) and preterm birth (PTB), are related to this increase of ROS. Antioxidants may be a promising tool in this population. However, clinical evidence on their use, especially those of natural origin, is scarce and controversial. Following PRISMA methodology, the current review addresses the use of natural antioxidants, such as epigallocatechin gallate (EGCG), melatonin and resveratrol (RESV), as well as other classical antioxidants (vitamin C and E) during the prenatal period as treatment of the above-mentioned complications. We review the effect of antioxidant supplementation on breast milk in lactating mothers. |
| first_indexed | 2024-03-09T11:15:01Z |
| format | Article |
| id | doaj.art-79a29d4a6abf48d4b6e77dd88e6ecd0b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:15:01Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-79a29d4a6abf48d4b6e77dd88e6ecd0b2023-12-01T00:34:17ZengMDPI AGAntioxidants2076-39212022-03-0111464810.3390/antiox11040648Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during PregnancyGiorgia Sebastiani0Elisabet Navarro-Tapia1Laura Almeida-Toledano2Mariona Serra-Delgado3Anna Lucia Paltrinieri4Óscar García-Algar5Vicente Andreu-Fernández6Department of Neonatology, Hospital Clínic-Maternitat, ICGON, BCNatal, 08028 Barcelona, SpainGrup de Recerca Infancia i Entorn (GRIE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainDepartment of Neonatology, Hospital Clínic-Maternitat, ICGON, BCNatal, 08028 Barcelona, SpainDepartment of Neonatology, Hospital Clínic-Maternitat, ICGON, BCNatal, 08028 Barcelona, SpainGrup de Recerca Infancia i Entorn (GRIE), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainDuring pregnancy, cycles of hypoxia and oxidative stress play a key role in the proper development of the fetus. Hypoxia during the first weeks is crucial for placental development, while the increase in oxygen due to the influx of maternal blood stimulates endothelial growth and angiogenesis. However, an imbalance in the number of oxidative molecules due to endogenous or exogenous factors can overwhelm defense systems and lead to excessive production of reactive oxygen species (ROS). Many pregnancy complications, generated by systemic inflammation and placental vasoconstriction, such as preeclampsia (PE), fetal growth restriction (FGR) and preterm birth (PTB), are related to this increase of ROS. Antioxidants may be a promising tool in this population. However, clinical evidence on their use, especially those of natural origin, is scarce and controversial. Following PRISMA methodology, the current review addresses the use of natural antioxidants, such as epigallocatechin gallate (EGCG), melatonin and resveratrol (RESV), as well as other classical antioxidants (vitamin C and E) during the prenatal period as treatment of the above-mentioned complications. We review the effect of antioxidant supplementation on breast milk in lactating mothers.https://www.mdpi.com/2076-3921/11/4/648antioxidantpregnancypreterm birthpre-eclampsiafetal growth restrictionbreastfeeding |
| spellingShingle | Giorgia Sebastiani Elisabet Navarro-Tapia Laura Almeida-Toledano Mariona Serra-Delgado Anna Lucia Paltrinieri Óscar García-Algar Vicente Andreu-Fernández Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy Antioxidants antioxidant pregnancy preterm birth pre-eclampsia fetal growth restriction breastfeeding |
| title | Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy |
| title_full | Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy |
| title_fullStr | Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy |
| title_full_unstemmed | Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy |
| title_short | Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy |
| title_sort | effects of antioxidant intake on fetal development and maternal neonatal health during pregnancy |
| topic | antioxidant pregnancy preterm birth pre-eclampsia fetal growth restriction breastfeeding |
| url | https://www.mdpi.com/2076-3921/11/4/648 |
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