The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data
Introduction: Agaricus blazei mushroom is used as a food and medicine, its effective composition is beta-glucan, which is used to treat some cancers and infections, including hepatitis C.Hepatitis C is an inflammatory disease that causes liver necrosis. Caspase2 protein is one of the factors promoti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Zabansaraye Parsian Novin Mehr Institute
2023-09-01
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| Series: | Journal of Current Oncology and Medical Sciences |
| Subjects: | |
| Online Access: | http://submission.journalofcoms.com/index.php/JCOMS/article/view/135 |
| _version_ | 1797668974468530176 |
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| author | Alireza Panahi Gholamreza Dadashi Oranj |
| author_facet | Alireza Panahi Gholamreza Dadashi Oranj |
| author_sort | Alireza Panahi |
| collection | DOAJ |
| description | Introduction: Agaricus blazei mushroom is used as a food and medicine, its effective composition is beta-glucan, which is used to treat some cancers and infections, including hepatitis C.Hepatitis C is an inflammatory disease that causes liver necrosis. Caspase2 protein is one of the factors promoting cell apoptosis and plays a role in tumor suppression. The purpose of this study is to determine the expression changes of the caspase2 gene and its effects on liver cancer.
Materials and Methods: In this project, raw expression data was obtained from the NCBI (National Center for Biotechnology Information) GEO (Gene Expression Omnibus) database section and using bioinformatics tools and methods and system biology such as Matlab (An abbreviation of "MATrix LABoratory), GEOR2 (Online software) and Cytoscape, the effect of consuming the desired mushroom on caspase2 gene expression was investigated.
Results: It was found that the beta-glucan combination has an increasing effect on target gene expression (p-value=0.05692).
Conclusion: The results show that the beta-glucan present in the mushroom can play a role as a prevention and even treatment of liver cancer by increasing the expression of caspase 2 protein by directing the damaged cell towards apoptosis. |
| first_indexed | 2024-03-11T20:37:23Z |
| format | Article |
| id | doaj.art-79a671495906499c93ae204db76645c5 |
| institution | Directory Open Access Journal |
| issn | 2783-3127 |
| language | English |
| last_indexed | 2024-03-11T20:37:23Z |
| publishDate | 2023-09-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj.art-79a671495906499c93ae204db76645c52023-10-02T05:47:07ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272023-09-0133526531The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray dataAlireza Panahi0Gholamreza Dadashi Oranj1Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, IranDepartment of Production Engineering and Plant Genetics, Faculty of Agricultural Sciences, University of Mohaghegh Ardabili, Ardabil, IranIntroduction: Agaricus blazei mushroom is used as a food and medicine, its effective composition is beta-glucan, which is used to treat some cancers and infections, including hepatitis C.Hepatitis C is an inflammatory disease that causes liver necrosis. Caspase2 protein is one of the factors promoting cell apoptosis and plays a role in tumor suppression. The purpose of this study is to determine the expression changes of the caspase2 gene and its effects on liver cancer. Materials and Methods: In this project, raw expression data was obtained from the NCBI (National Center for Biotechnology Information) GEO (Gene Expression Omnibus) database section and using bioinformatics tools and methods and system biology such as Matlab (An abbreviation of "MATrix LABoratory), GEOR2 (Online software) and Cytoscape, the effect of consuming the desired mushroom on caspase2 gene expression was investigated. Results: It was found that the beta-glucan combination has an increasing effect on target gene expression (p-value=0.05692). Conclusion: The results show that the beta-glucan present in the mushroom can play a role as a prevention and even treatment of liver cancer by increasing the expression of caspase 2 protein by directing the damaged cell towards apoptosis.http://submission.journalofcoms.com/index.php/JCOMS/article/view/135beta-glucanagaricus blazeihepatitis ccaspase 2microarraysystem biology |
| spellingShingle | Alireza Panahi Gholamreza Dadashi Oranj The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data Journal of Current Oncology and Medical Sciences beta-glucan agaricus blazei hepatitis c caspase 2 microarray system biology |
| title | The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data |
| title_full | The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data |
| title_fullStr | The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data |
| title_full_unstemmed | The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data |
| title_short | The effect of consumption of Agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis C patients using system biology and microarray data |
| title_sort | effect of consumption of agaricus blazei edible mushroom on caspase 2 gene expression in hepatitis c patients using system biology and microarray data |
| topic | beta-glucan agaricus blazei hepatitis c caspase 2 microarray system biology |
| url | http://submission.journalofcoms.com/index.php/JCOMS/article/view/135 |
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