Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions
Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/18/9950 |
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| author | Gianluca Businello Valentina Angerilli Paola Parente Stefano Realdon Edoardo Savarino Fabio Farinati Federica Grillo Alessandro Vanoli Francesca Galuppini Silvia Paccagnella Gianmaria Pennelli Luca Mastracci Luca Saragoni Matteo Fassan |
| author_facet | Gianluca Businello Valentina Angerilli Paola Parente Stefano Realdon Edoardo Savarino Fabio Farinati Federica Grillo Alessandro Vanoli Francesca Galuppini Silvia Paccagnella Gianmaria Pennelli Luca Mastracci Luca Saragoni Matteo Fassan |
| author_sort | Gianluca Businello |
| collection | DOAJ |
| description | Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process. |
| first_indexed | 2024-03-10T07:35:48Z |
| format | Article |
| id | doaj.art-79a6948860eb4c94bc59ae5621e4a089 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:35:48Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-79a6948860eb4c94bc59ae5621e4a0892023-11-22T13:30:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-012218995010.3390/ijms22189950Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive LesionsGianluca Businello0Valentina Angerilli1Paola Parente2Stefano Realdon3Edoardo Savarino4Fabio Farinati5Federica Grillo6Alessandro Vanoli7Francesca Galuppini8Silvia Paccagnella9Gianmaria Pennelli10Luca Mastracci11Luca Saragoni12Matteo Fassan13Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, ItalySurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, ItalyPathology Unit, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyVeneto Institute of Oncology (IOV-IRCCS), 35128 Padua, ItalyDivision of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35121 Padua, ItalyDivision of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35121 Padua, ItalyAnatomic Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DICS), University of Genova, 16132 Genova, ItalyAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, 27100 Pavia, ItalySurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, ItalySurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, ItalySurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, ItalyAnatomic Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DICS), University of Genova, 16132 Genova, ItalyUO Anatomia Patologica, Ospedale G.B. Morgagni-L. Pierantoni, 47121 Forlì, ItalySurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, ItalyGastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process.https://www.mdpi.com/1422-0067/22/18/9950gastric carcinomapre-neoplastic lesionsgastric carcinogenesisbiomarkerspathology |
| spellingShingle | Gianluca Businello Valentina Angerilli Paola Parente Stefano Realdon Edoardo Savarino Fabio Farinati Federica Grillo Alessandro Vanoli Francesca Galuppini Silvia Paccagnella Gianmaria Pennelli Luca Mastracci Luca Saragoni Matteo Fassan Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions International Journal of Molecular Sciences gastric carcinoma pre-neoplastic lesions gastric carcinogenesis biomarkers pathology |
| title | Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions |
| title_full | Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions |
| title_fullStr | Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions |
| title_full_unstemmed | Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions |
| title_short | Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions |
| title_sort | molecular landscapes of gastric pre neoplastic and pre invasive lesions |
| topic | gastric carcinoma pre-neoplastic lesions gastric carcinogenesis biomarkers pathology |
| url | https://www.mdpi.com/1422-0067/22/18/9950 |
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