Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation

Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation

Background/Aims: Chondrocyte apoptosis is largely responsible for cartilage degeneration in osteoarthritis (OA). Interleukin-1 beta (IL-1β) is widely used as a chondrocyte apoptosis-inducing agent, while lactoferrin (LF) is an anabolic reagent which has the potential to inhibit chondrocyte apoptosis...

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Bibliographic Details
Main Authors: Huaming Xue, Yihui Tu, Tong Ma, Xiaodong Liu, Tao Wen, Minwei Cai, Zhidao Xia, Jiong Mei
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Lactoferrin
Osteoarthritis
Chondrocyte
Apoptosis
Online Access:http://www.karger.com/Article/FullText/430206

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