Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology
Neuropeptide Y is widely distributed within the body and has long been implicated as a contributor to skin disease based on the correlative clinical data. However, until recently, there have been few empirical investigations to determine whether NPY has a pathophysiological role in the skin. Due to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.838434/full |
| _version_ | 1818320259903389696 |
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| author | Zoya T. Anderson Alex D. Dawson Andrzej T. Slominski Andrzej T. Slominski Melissa L. Harris |
| author_facet | Zoya T. Anderson Alex D. Dawson Andrzej T. Slominski Andrzej T. Slominski Melissa L. Harris |
| author_sort | Zoya T. Anderson |
| collection | DOAJ |
| description | Neuropeptide Y is widely distributed within the body and has long been implicated as a contributor to skin disease based on the correlative clinical data. However, until recently, there have been few empirical investigations to determine whether NPY has a pathophysiological role in the skin. Due to appearance-altering phenotypes of atopic dermatitis, psoriasis, and vitiligo, those suffering from these diseases often face multiple forms of negative social attention. This often results in psychological stress, which has been shown to exacerbate inflammatory skin diseases – creating a vicious cycle that perpetuates disease. This has been shown to drive severe depression, which has resulted in suicidal ideation being a comorbidity of these diseases. Herein, we review what is currently known about the associations of NPY with skin diseases and stress. We also review and provide educated guessing what the effects NPY can have in the skin. Inflammatory skin diseases can affect physical appearance to have significant, negative impacts on quality of life. No cure exists for these conditions, highlighting the need for identification of novel proteins/neuropetides, like NPY, that can be targeted therapeutically. This review sets the stage for future investigations into the role of NPY in skin biology and pathology to stimulate research on therapeutic targeting NPY signaling in order to combat inflammatory skin diseases. |
| first_indexed | 2024-12-13T10:22:10Z |
| format | Article |
| id | doaj.art-79a9f11542984cfc9c90344937dcba9d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T10:22:10Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-79a9f11542984cfc9c90344937dcba9d2022-12-21T23:51:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.838434838434Current Insights Into the Role of Neuropeptide Y in Skin Physiology and PathologyZoya T. Anderson0Alex D. Dawson1Andrzej T. Slominski2Andrzej T. Slominski3Melissa L. Harris4Department of Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Dermatology, Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL, United StatesVeteran Administration Medical Center, Birmingham, AL, United StatesDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesNeuropeptide Y is widely distributed within the body and has long been implicated as a contributor to skin disease based on the correlative clinical data. However, until recently, there have been few empirical investigations to determine whether NPY has a pathophysiological role in the skin. Due to appearance-altering phenotypes of atopic dermatitis, psoriasis, and vitiligo, those suffering from these diseases often face multiple forms of negative social attention. This often results in psychological stress, which has been shown to exacerbate inflammatory skin diseases – creating a vicious cycle that perpetuates disease. This has been shown to drive severe depression, which has resulted in suicidal ideation being a comorbidity of these diseases. Herein, we review what is currently known about the associations of NPY with skin diseases and stress. We also review and provide educated guessing what the effects NPY can have in the skin. Inflammatory skin diseases can affect physical appearance to have significant, negative impacts on quality of life. No cure exists for these conditions, highlighting the need for identification of novel proteins/neuropetides, like NPY, that can be targeted therapeutically. This review sets the stage for future investigations into the role of NPY in skin biology and pathology to stimulate research on therapeutic targeting NPY signaling in order to combat inflammatory skin diseases.https://www.frontiersin.org/articles/10.3389/fendo.2022.838434/fullneuropeptide Yskinphysiologypathologystress |
| spellingShingle | Zoya T. Anderson Alex D. Dawson Andrzej T. Slominski Andrzej T. Slominski Melissa L. Harris Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology Frontiers in Endocrinology neuropeptide Y skin physiology pathology stress |
| title | Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology |
| title_full | Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology |
| title_fullStr | Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology |
| title_full_unstemmed | Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology |
| title_short | Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology |
| title_sort | current insights into the role of neuropeptide y in skin physiology and pathology |
| topic | neuropeptide Y skin physiology pathology stress |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.838434/full |
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