Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature
Abstract Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-017-0564-6 |
| _version_ | 1818837474675261440 |
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| author | Olivia Wilcox Mohamed Hassanein John Armstrong Nader Kassis |
| author_facet | Olivia Wilcox Mohamed Hassanein John Armstrong Nader Kassis |
| author_sort | Olivia Wilcox |
| collection | DOAJ |
| description | Abstract Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS syndrome with 23 cases reported to date. Case presentation We described a case of a 39 year-old man who was treated with vancomycin for osteomyelitis of the foot. The patient subsequently developed acute respiratory distress syndrome (ARDS) followed by rash and acute interstitial nephritis. These symptoms were improved by withdrawal of vancomycin and a pulsed corticosteroid regimen. According to the European Registry of Severe Cutaneous Adverse Reaction Criteria (RegiSCAR) (Kardaun et al, British Journal of Dermatology, 169:1071-1080, 2013), the probability of vancomycin induced DRESS syndrome was scored as “Definite”. A literature search of vancomycin induced DRESS syndrome was also performed and the overall pulmonary involvement was estimated as 5%. To our knowledge, this was the first case reported with pulmonary involvement as the initial symptom. Conclusion This is the first case to report pulmonary manifestation as the initial symptom in vancomycin induced DRESS syndrome. Prompt recognition of this entity can expedite proper treatment and hasten recovery. |
| first_indexed | 2024-12-19T03:23:05Z |
| format | Article |
| id | doaj.art-79acc4eb96f74bbc9a0edc4516d7e120 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-19T03:23:05Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-79acc4eb96f74bbc9a0edc4516d7e1202022-12-21T20:37:43ZengBMCBMC Pulmonary Medicine1471-24662017-12-011711610.1186/s12890-017-0564-6Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literatureOlivia Wilcox0Mohamed Hassanein1John Armstrong2Nader Kassis3Department of Internal Medicine, Michigan State UniversityDepartment of Internal Medicine, Michigan State UniversityPulmonary Critical Care, Sparrow Medical GroupNephrology, Sparrow Medical GroupAbstract Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS syndrome with 23 cases reported to date. Case presentation We described a case of a 39 year-old man who was treated with vancomycin for osteomyelitis of the foot. The patient subsequently developed acute respiratory distress syndrome (ARDS) followed by rash and acute interstitial nephritis. These symptoms were improved by withdrawal of vancomycin and a pulsed corticosteroid regimen. According to the European Registry of Severe Cutaneous Adverse Reaction Criteria (RegiSCAR) (Kardaun et al, British Journal of Dermatology, 169:1071-1080, 2013), the probability of vancomycin induced DRESS syndrome was scored as “Definite”. A literature search of vancomycin induced DRESS syndrome was also performed and the overall pulmonary involvement was estimated as 5%. To our knowledge, this was the first case reported with pulmonary involvement as the initial symptom. Conclusion This is the first case to report pulmonary manifestation as the initial symptom in vancomycin induced DRESS syndrome. Prompt recognition of this entity can expedite proper treatment and hasten recovery.http://link.springer.com/article/10.1186/s12890-017-0564-6Drug reactionEosinophiliaDressVancomycinAcute respiratory distress syndromeARDS |
| spellingShingle | Olivia Wilcox Mohamed Hassanein John Armstrong Nader Kassis Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature BMC Pulmonary Medicine Drug reaction Eosinophilia Dress Vancomycin Acute respiratory distress syndrome ARDS |
| title | Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature |
| title_full | Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature |
| title_fullStr | Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature |
| title_full_unstemmed | Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature |
| title_short | Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature |
| title_sort | case report atypical presentation of vancomycin induced dress syndrome a case report and review of the literature |
| topic | Drug reaction Eosinophilia Dress Vancomycin Acute respiratory distress syndrome ARDS |
| url | http://link.springer.com/article/10.1186/s12890-017-0564-6 |
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