The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism

The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism

Summary: CD4+ T cells are critical for adaptive immunity, differentiating into distinct effector and regulatory subsets. Although the transcriptional programs underlying their differentiation are known, recent research has highlighted the importance of mRNA translation in determining protein abundan...

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Bibliographic Details
Main Authors: Roman Istomine, Tho-Alfakar Al-Aubodah, Fernando Alvarez, Jacob A. Smith, Carston Wagner, Ciriaco A. Piccirillo
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Immunology
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007605

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