The Utilization Pattern of Caspofungin in an Educational Hospital
Purpose: Caspofungin is prescribed for systemic treatment of fungal infections and correct prescription pattern is an issue of importance. Hence in this study the Caspofungin utilization and the frequency rate of medication errors were investigated at a training hospital in a developing country. Met...
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| Format: | Article |
| Language: | English |
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Research Center for Rational Use of Drugs (RCRUD)
2019-12-01
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| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/266 |
| _version_ | 1818807532300271616 |
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| author | Soodeh Ramezaninejad Atefeh Amouzegar Sohrab Aghabeigi Maryam Farasati Nasab Mitra Ranjbar Mahin Jamshidi Behrooz Ghanbari Nashmin Pakdaman Maryam Khorsani |
| author_facet | Soodeh Ramezaninejad Atefeh Amouzegar Sohrab Aghabeigi Maryam Farasati Nasab Mitra Ranjbar Mahin Jamshidi Behrooz Ghanbari Nashmin Pakdaman Maryam Khorsani |
| author_sort | Soodeh Ramezaninejad |
| collection | DOAJ |
| description | Purpose: Caspofungin is prescribed for systemic treatment of fungal infections and correct prescription pattern is an issue of importance. Hence in this study the Caspofungin utilization and the frequency rate of medication errors were investigated at a training hospital in a developing country.
Methods: In this cross-sectional descriptive comparative study 43 consecutive patients receiving Caspofungin in Firoozgar Hospital, Tehran, Iran from March to September 2017 were enrolled. The prescription frequency of the drug was compared with the national data and the suggested rates by World Health Organization.
Results: The prescription rate was higher in Intensive Care Unit with 72.1% rate. Infectious disease specialists were responsible for Caspofungin prescription only in 11 cases (25.5%). The cause of Caspofungin prescription was unknown in 18.6% of cases; but experimental treatment for febrile neutropenia and ICU patients with Candida Score > 2.5 were the most known causes. The drug administration in 11 cases (25.6%) occurred in less than one hour. The indication of treatment was incorrect in 12 out of 43 cases (28%). On the first day of the treatment a dose of both 70 mg and 50 mg was prescribed, which was higher than the appropriate dose and also it was lower than the optimal dose in five cases (83.7%). The mean treatment duration was 10.88 ± 5.35 days ranging from 2 to 24 days. The duration of treatment was correct in 20 cases (46.5%) and incorrect in 23 patients (53.5%).
Conclusion: According to the obtained results, it may be concluded that in comparison with the international guidelines there are multiple discordance in our setting including inappropriate duration, continuation, and indications. Hence these should be announced to the physicians for further cautions in this area, and it is better to consult with infectious diseases specialists for the administration of anti-fungal drugs. |
| first_indexed | 2024-12-18T19:27:10Z |
| format | Article |
| id | doaj.art-79ae89f62c0f4345a92ac4939a4847fe |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-12-18T19:27:10Z |
| publishDate | 2019-12-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-79ae89f62c0f4345a92ac4939a4847fe2022-12-21T20:55:51ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092019-12-017310.18502/jpc.v7i3.2352266The Utilization Pattern of Caspofungin in an Educational HospitalSoodeh Ramezaninejad0Atefeh Amouzegar1Sohrab Aghabeigi2Maryam Farasati Nasab3Mitra Ranjbar4Mahin Jamshidi5Behrooz Ghanbari6Nashmin Pakdaman7Maryam Khorsani8Department of Internal Medicine, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranDepartment of Nephrology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranDepartment of Clinical Pharmacy, Firoozgar Clinical Research Development Center (FCRDC), School of Pharmacy International Campus. Iran University of Medical Sciences, Tehran, IranAntimicrobial Resistance Research Center, Institute of Immunology and Infectious Disease, Iran University of Medical Sciences, Tehran, IranAntimicrobial Resistance Research Center, Institute of Immunology and Infectious Disease, Iran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranFiroozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranMA Student. English Language and Literature Department, Faculty of Foreign Languages and Literature, University of Tehran, Tehran, IranPurpose: Caspofungin is prescribed for systemic treatment of fungal infections and correct prescription pattern is an issue of importance. Hence in this study the Caspofungin utilization and the frequency rate of medication errors were investigated at a training hospital in a developing country. Methods: In this cross-sectional descriptive comparative study 43 consecutive patients receiving Caspofungin in Firoozgar Hospital, Tehran, Iran from March to September 2017 were enrolled. The prescription frequency of the drug was compared with the national data and the suggested rates by World Health Organization. Results: The prescription rate was higher in Intensive Care Unit with 72.1% rate. Infectious disease specialists were responsible for Caspofungin prescription only in 11 cases (25.5%). The cause of Caspofungin prescription was unknown in 18.6% of cases; but experimental treatment for febrile neutropenia and ICU patients with Candida Score > 2.5 were the most known causes. The drug administration in 11 cases (25.6%) occurred in less than one hour. The indication of treatment was incorrect in 12 out of 43 cases (28%). On the first day of the treatment a dose of both 70 mg and 50 mg was prescribed, which was higher than the appropriate dose and also it was lower than the optimal dose in five cases (83.7%). The mean treatment duration was 10.88 ± 5.35 days ranging from 2 to 24 days. The duration of treatment was correct in 20 cases (46.5%) and incorrect in 23 patients (53.5%). Conclusion: According to the obtained results, it may be concluded that in comparison with the international guidelines there are multiple discordance in our setting including inappropriate duration, continuation, and indications. Hence these should be announced to the physicians for further cautions in this area, and it is better to consult with infectious diseases specialists for the administration of anti-fungal drugs.https://jpc.tums.ac.ir/index.php/jpc/article/view/266CaspofunginCandida infectionAntimicrobial therapyAntifungal drugMedication error |
| spellingShingle | Soodeh Ramezaninejad Atefeh Amouzegar Sohrab Aghabeigi Maryam Farasati Nasab Mitra Ranjbar Mahin Jamshidi Behrooz Ghanbari Nashmin Pakdaman Maryam Khorsani The Utilization Pattern of Caspofungin in an Educational Hospital Journal of Pharmaceutical Care Caspofungin Candida infection Antimicrobial therapy Antifungal drug Medication error |
| title | The Utilization Pattern of Caspofungin in an Educational Hospital |
| title_full | The Utilization Pattern of Caspofungin in an Educational Hospital |
| title_fullStr | The Utilization Pattern of Caspofungin in an Educational Hospital |
| title_full_unstemmed | The Utilization Pattern of Caspofungin in an Educational Hospital |
| title_short | The Utilization Pattern of Caspofungin in an Educational Hospital |
| title_sort | utilization pattern of caspofungin in an educational hospital |
| topic | Caspofungin Candida infection Antimicrobial therapy Antifungal drug Medication error |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/266 |
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