Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy
Antimicrobial stewardship programs (ASPs) have been suggested to reduce antimicrobial resistance phenomena in veterinary medicine, as antibiotics are commonly used without microbiological confirmation. The aim of the present study is to design a specific working flow for a tailored antimicrobial tre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/5/562 |
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| author | Cristina Vercelli Massimiliano Della Ricca Mariachiara Re Graziana Gambino Giovanni Re |
| author_facet | Cristina Vercelli Massimiliano Della Ricca Mariachiara Re Graziana Gambino Giovanni Re |
| author_sort | Cristina Vercelli |
| collection | DOAJ |
| description | Antimicrobial stewardship programs (ASPs) have been suggested to reduce antimicrobial resistance phenomena in veterinary medicine, as antibiotics are commonly used without microbiological confirmation. The aim of the present study is to design a specific working flow for a tailored antimicrobial treatment in the case of canine and feline urinary tract infections (UTIs). Urine samples were collected by cystocentesis from 16 dogs and 12 cats presenting acute signs of UTI. The therapy was decided according to the minimal inhibitory concentration, and it was possible to monitor 14 dogs and 11 cats. Rescue therapy (amoxicillin and clavulanic acid) was included in emergency cases. <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, and <i>Streptococcus canis</i> were isolated in dogs, and <i>Escherichia coli</i>, <i>Staphylococcus pseudintermedius</i>, and <i>Staphylococcus aureus</i> were isolated in cats. No multidrug-resistant strains were detected, but all <i>Staphylococci</i> were methicillin resistant. Only one cat received rescue therapy, and only one dog was recruited. Dogs were treated with tetracycline (1/14), fluoroquinolones (6/14), beta-lactams (6/14), and gentamicin (1/14), while cats received fluoroquinolones (3/11), nitrofurans (1/11), clindamycin (1/11), and beta-lactams (6/11). The success rate was very high. Our findings are interesting because this is the first ASP in Italy, and it may be used as a model to develop ASPs for other pathologies. |
| first_indexed | 2024-03-10T11:31:45Z |
| format | Article |
| id | doaj.art-79b017485dcc4584acbc381afa5b140e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T11:31:45Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-79b017485dcc4584acbc381afa5b140e2023-11-21T19:13:25ZengMDPI AGAntibiotics2079-63822021-05-0110556210.3390/antibiotics10050562Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest ItalyCristina Vercelli0Massimiliano Della Ricca1Mariachiara Re2Graziana Gambino3Giovanni Re4Department of Veterinary Science, University of Turin, 10095 Grugliasco, TO, ItalyCentro Veterinario Torinese (CVT) Hospital, 10098 Rivoli, TO, ItalyCentro Veterinario Torinese (CVT) Hospital, 10098 Rivoli, TO, ItalyDepartment of Veterinary Science, University of Turin, 10095 Grugliasco, TO, ItalyDepartment of Veterinary Science, University of Turin, 10095 Grugliasco, TO, ItalyAntimicrobial stewardship programs (ASPs) have been suggested to reduce antimicrobial resistance phenomena in veterinary medicine, as antibiotics are commonly used without microbiological confirmation. The aim of the present study is to design a specific working flow for a tailored antimicrobial treatment in the case of canine and feline urinary tract infections (UTIs). Urine samples were collected by cystocentesis from 16 dogs and 12 cats presenting acute signs of UTI. The therapy was decided according to the minimal inhibitory concentration, and it was possible to monitor 14 dogs and 11 cats. Rescue therapy (amoxicillin and clavulanic acid) was included in emergency cases. <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, and <i>Streptococcus canis</i> were isolated in dogs, and <i>Escherichia coli</i>, <i>Staphylococcus pseudintermedius</i>, and <i>Staphylococcus aureus</i> were isolated in cats. No multidrug-resistant strains were detected, but all <i>Staphylococci</i> were methicillin resistant. Only one cat received rescue therapy, and only one dog was recruited. Dogs were treated with tetracycline (1/14), fluoroquinolones (6/14), beta-lactams (6/14), and gentamicin (1/14), while cats received fluoroquinolones (3/11), nitrofurans (1/11), clindamycin (1/11), and beta-lactams (6/11). The success rate was very high. Our findings are interesting because this is the first ASP in Italy, and it may be used as a model to develop ASPs for other pathologies.https://www.mdpi.com/2079-6382/10/5/562antibiotic stewardshipurinary tract infectiondogcatlocal sensitivity |
| spellingShingle | Cristina Vercelli Massimiliano Della Ricca Mariachiara Re Graziana Gambino Giovanni Re Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy Antibiotics antibiotic stewardship urinary tract infection dog cat local sensitivity |
| title | Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy |
| title_full | Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy |
| title_fullStr | Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy |
| title_full_unstemmed | Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy |
| title_short | Antibiotic Stewardship for Canine and Feline Acute Urinary Tract Infection: An Observational Study in a Small Animal Hospital in Northwest Italy |
| title_sort | antibiotic stewardship for canine and feline acute urinary tract infection an observational study in a small animal hospital in northwest italy |
| topic | antibiotic stewardship urinary tract infection dog cat local sensitivity |
| url | https://www.mdpi.com/2079-6382/10/5/562 |
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